Evidence map›Paper›PMID 38004156›Full record

ReviewNutrients2023

The Remaining Challenge to Diagnose and Manage Cow's Milk Allergy: An Opinion Paper to Daily Clinical Practice.

Yvan Vandenplas, Rosan Meyer, Anna Nowak-Wegrzyn, Silvia Salvatore, Carina Venter, Mario C Vieira

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Review
  6. Article
  7. Cow milk protein allergy mimics in infancy.World journal of clinical pediatrics · 2025
    Review
  8. Observational
  9. Article
  10. Review
  11. Article
  12. Observational
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 6 countries.

Yvan VandenplasUZ Brussel, KidZ Health Castle, Vrije Universiteit Brussel (VUB), 1090 Brussels, Belgium.ORCID 0000-0002-1862-8651
Rosan MeyerDepartment Paediatrics, Imperial College London, London SW7 2BX, UK.
Anna Nowak-WegrzynDepartment of Pediatrics, NYU Grossman School of Medicine, Hassenfeld Children's Hospital, New York, NY 10016, USA.
Silvia SalvatoreDepartment of Pediatrics, Hospital "F. Del Ponte", University of Insubria, 21100 Varese, Italy.
Carina VenterSection of Pediatric Allergy and Immunology, Children's Hospital Colorado, University of Colorado, Aurora, CO 80045, USA.ORCID 0000-0002-7473-5355
Mario C VieiraCenter for Pediatric Gastroenterology, Hospital Pequeno Príncipe, Curitiba 80250, Brazil.ORCID 0000-0003-3405-2995
Children's Hospital Colorado · USHospital Erasto Gaertner · BRUniversity of Insubria · ITUniversity of Warmia and Mazury in Olsztyn · PLUniversity of Winchester · GBVrije Universiteit Brussel · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Guidelines and recommendations for the diagnosis and management of cow's milk allergy (CMA) in childhood are based on scientific review of the available evidence. While this approach is the most rigorous, guidelines may not fully address all scenarios encountered by clinicians. Many symptoms of CMA overlap with other common childhood illnesses and are subjectively reported by the caregivers of the infant, as is the interpretation of the dietary interventions. Additionally, many healthcare professionals and caregivers do not follow the recommendations to perform an oral food challenge or reintroduction of cow's milk after a diagnostic elimination diet because (1) the infant is doing well and (2) the carer's fear of symptoms relapsing with this procedure. As a result, CMA in infants may be either under-diagnosed leading to reduced quality of life for families or over-diagnosed, resulting in unnecessary long-term elimination diets and increasing the risk for nutritional deficiencies. This paper discusses some of these controversial topics, focusing on misdiagnosis and mismanagement in clinical practice. The lack of objective diagnostic criteria can hamper the diagnosis and management of CMA in daily practice.

Indexed as

MalnutritionMilk HypersensitivityAllergensAnimalsCattleFemaleHumansInfantMilkQuality of LifeAllergensamino acid formulacow’s milk allergydiagnosisextensive hydrolysatehydrolyzed rice formulaIgE mediatedmanagementnon-IgE mediatedprevalencesoy formula

Identifiers

PMID38004156
PMCPMC10675216
OpenAlexW4388637423

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.