Evidence map›Paper›PMID 38003780›Full record

ArticlePathogens (Basel, Switzerland)2023

CRP Monitoring in Early Hospitalization: Implications for Predicting Outcomes in Patients with COVID-19.

Byron Avihai, Erin P Sundel, Eileen Lee, Patricia J Greenberg, Brennan P Cook, Nicole J Altomare, Tomohiro M Ko, Angelo I Chaia, Payal D Parikh, Martin J Blaser

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Byron AvihaiRobert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0001-5226-9464
Erin P SundelRobert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.
Eileen LeeRobert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0003-2316-2419
Patricia J GreenbergDepartment of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ 08854, USA.
Brennan P CookRobert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.
Nicole J AltomareRobert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.
Tomohiro M KoRobert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.
Angelo I ChaiaRobert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.
Payal D ParikhRobert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.
Martin J BlaserRobert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0003-2447-2443

Funding

New Jersey Alliance for Clinical Translational Science: NJ ACTSUL1TR003017 · NCATS · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI PANETTIERI, REYNOLD ALEXANDER · 2019 to 2023
$28.9M
Cohort and biomarkers for COVID-19 severity, natural history, and reinfectionR01AI158911 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI BARRETT, EMILY S, BLASER, MARTIN J · 2021 to 2023
$2.6M
NCATS NIH HHS UL1 TR003017NCATS NIH HHS UL1TR003017NIAID NIH HHS R01 AI158911
6 · The paper itself

Abstract

Elevated C-reactive protein (CRP) levels have been associated with poorer COVID-19 outcomes. While baseline CRP levels are higher in women, obese individuals, and older adults, the relationship between CRP, sex, body mass index (BMI), age, and COVID-19 outcomes remains unknown. To investigate, we performed a retrospective analysis on 824 adult patients with COVID-19 admitted during the first pandemic wave, of whom 183 (22.2%) died. The maximum CRP value over the first five hospitalization days better predicted hospitalization outcome than the CRP level at admission, as a maximum CRP > 10 mg/dL independently quadrupled the risk of death (

Indexed as

COVID-19 hyperinflammatory syndromesCOVID-19 risk factorsC-reactive protein

Identifiers

PMID38003780
PMCPMC10675493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.