Evidence map›Paper›PMID 38003754›Full record

ArticlePathogens (Basel, Switzerland)2023

Enolase Inhibitors as Early Lead Therapeutics against

Colm P Roster, Danielle LaVigne, Jillian E Milanes, Emily Knight, Heidi D Anderson, Sabrina Pizarro, Elijah M Harding, Meredith T Morris, Victoria C Yan, Cong-Dat Pham and 8 more

Open access · goldAbstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Colm P RosterEukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, SC 29634, USA.
Danielle LaVigneEukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, SC 29634, USA.
Jillian E MilanesEukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, SC 29634, USA.ORCID 0000-0002-4872-082X
Emily KnightEukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, SC 29634, USA.
Heidi D AndersonEukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, SC 29634, USA.
Sabrina PizarroEukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, SC 29634, USA.
Elijah M HardingEukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, SC 29634, USA.
Meredith T MorrisEukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, SC 29634, USA.ORCID 0000-0002-6455-0197
Victoria C YanDepartment of Cancer Systems Imaging, UT MD Anderson Cancer Center, Houston, TX 77030, USA.
Cong-Dat PhamDepartment of Cancer Systems Imaging, UT MD Anderson Cancer Center, Houston, TX 77030, USA.
Florian MullerSporos Bioventures, 3000 Bissonnet, Belmont Suite 5303, Houston, TX 77005, USA.
Samuel KwainEukaryotic Pathogens Innovation Center, Department of Chemistry, Clemson University, Clemson, SC 29634, USA.ORCID 0000-0002-4065-2025
Kerrick C ReesEukaryotic Pathogens Innovation Center, Department of Chemistry, Clemson University, Clemson, SC 29634, USA.ORCID 0000-0002-1958-4777
Brian DominyDepartment of Chemistry, Clemson University, Clemson, SC 29634, USA.
Daniel C WhiteheadEukaryotic Pathogens Innovation Center, Department of Chemistry, Clemson University, Clemson, SC 29634, USA.ORCID 0000-0001-6881-2628
Md Nasir UddinDepartment of Cancer Systems Imaging, UT MD Anderson Cancer Center, Houston, TX 77030, USA.
Steven W MillwardDepartment of Cancer Systems Imaging, UT MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-3231-7075
James C MorrisEukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, SC 29634, USA.ORCID 0000-0003-2515-5714
Clemson University · USThe University of Texas MD Anderson Cancer Center · USBioVentures (United States) · US

Funding

Regulation of Cryptosporidium DevelopmentP20GM146584 · NIGMS · CLEMSON UNIVERSITY · PI JAMES Culvin MORRIS · 2022 to 2026
$13.5M
Development of a multiplexed assay in kinetoplastid parasites to identify probes for glycolysisR01AI156382 · NIAID · CLEMSON UNIVERSITY · PI CHRISTENSEN, KENNETH A, GOLDEN, JENNIFER E. · 2021 to 2024
$1.9M
Pro-Drug Enolase Inhibitors in Precision OncologyR01CA231509 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MILLWARD, STEVEN W · 2021 to 2025
$1.6M
Enolase inhibitors as therapeutic leads for Naegleria fowleri infectionsR21AI171217 · NIAID · CLEMSON UNIVERSITY · PI MORRIS, JAMES CULVIN, MOSEMAN, E. ASHLEY · 2023 to 2024
$468k
NCI NIH HHS R01 CA231509NIAID NIH HHS R01 AI156382NIAID NIH HHS R21 AI171217NIGMS NIH HHS P20 GM146584
6 · The paper itself

Abstract

Glucose metabolism is critical for the African trypanosome,

Indexed as

African trypanosomeenolaseglycolysisinhibitorsTrypanosoma brucei

Identifiers

PMID38003754
PMCPMC10675445
OpenAlexW4388020759

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.