Evidence map›Paper›PMID 38003737›Full record

ReviewInternational journal of molecular sciences2023

Virus-Encoded Circular RNAs: Role and Significance in Viral Infections.

Giuseppe Sberna, Fabrizio Maggi, Alessandra Amendola

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Giuseppe SbernaLaboratory of Virology and Biosafety Laboratories, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.ORCID 0000-0003-0955-2074
Fabrizio MaggiLaboratory of Virology and Biosafety Laboratories, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.ORCID 0000-0001-7489-5271
Alessandra AmendolaLaboratory of Virology and Biosafety Laboratories, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.ORCID 0000-0002-7063-0222

Funding

Ministero della Salute Programme CCM 2020 Ricerca Corrente - Linea 1 on emerging and re-emerging infections
6 · The paper itself

Abstract

Circular RNAs (circRNAs) have been the focus of intense scientific research to understand their biogenesis, mechanisms of action and regulatory functions. CircRNAs are single stranded, covalently closed RNA molecules lacking the 5'-terminal cap and the 3'-terminal polyadenine chain, characteristics that make them very stable and resistant. Synthesised by both cells and viruses, in the past circRNAs were considered to have no precise function. Today, increasing evidence shows that circRNAs are ubiquitous, some of them are tissue- and cell-specific, and critical in multiple regulatory processes (i.e., infections, inflammation, oncogenesis, gene expression). Moreover, circRNAs are emerging as important biomarkers of viral infection and disease progression. In this review, we provided an updated overview of current understanding of virus-encoded and cellular-encoded circRNAs and their involvement in cellular pathways during viral infection.

Indexed as

Virus DiseasesVirusesBiomarkersHumansRNARNA, CircularBiomarkersRNARNA, Circularbiomarkers of infectioncircRNAcircular RNAnon-coding RNAviral infection

Identifiers

PMID38003737
PMCPMC10671809

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.