Evidence map›Paper›PMID 38003736›Full record

ArticleInternational journal of molecular sciences2023

Distinct HAND2/HAND2-AS1 Expression Levels May Fine-Tune Mesenchymal and Epithelial Cell Plasticity of Human Mesenchymal Stem Cells.

Rachel Vazana-Netzarim, Yishay Elmalem, Shachar Sofer, Hod Bruck, Naama Danino, Udi Sarig

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rachel Vazana-NetzarimThe Dr. Miriam and Sheldon Adelson School of Medicine, Department of Morphological Sciences and Teratology, Ariel University, Ariel 4070000, Israel.
Yishay ElmalemDepartment of Chemical Engineering, Faculty of Engineering, Ariel University, Ariel 4070000, Israel.
Shachar SoferDepartment of Chemical Engineering, Faculty of Engineering, Ariel University, Ariel 4070000, Israel.ORCID 0009-0000-0199-0681
Hod BruckDepartment of Chemical Engineering, Faculty of Engineering, Ariel University, Ariel 4070000, Israel.
Naama DaninoThe Dr. Miriam and Sheldon Adelson School of Medicine, Department of Morphological Sciences and Teratology, Ariel University, Ariel 4070000, Israel.
Udi SarigThe Dr. Miriam and Sheldon Adelson School of Medicine, Department of Morphological Sciences and Teratology, Ariel University, Ariel 4070000, Israel.ORCID 0000-0001-5260-4023

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We previously developed several successful decellularization strategies that yielded porcine cardiac extracellular matrices (pcECMs) exhibiting tissue-specific bioactivity and bioinductive capacity when cultured with various pluripotent and multipotent stem cells. Here, we study the tissue-specific effects of the pcECM on seeded human mesenchymal stem cell (hMSC) phenotypes using reverse transcribed quantitative polymerase chain reaction (RT-qPCR) arrays for cardiovascular related gene expression. We further corroborated interesting findings at the protein level (flow cytometry and immunological stains) as well as bioinformatically using several mRNA sequencing and protein databases of normal and pathologic adult and embryonic (organogenesis stage) tissue expression. We discovered that upon the seeding of hMSCs on the pcECM, they displayed a partial mesenchymal-to-epithelial transition (MET) toward endothelial phenotypes (CD31

Indexed as

Mesenchymal Stem CellsMicroRNAsRNA, Long NoncodingAdultAnimalsCell Line, TumorCell MovementCell ProliferationDown-RegulationEpithelial CellsEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansRNA, MessengerSwineTranscription FactorsMicroRNAsRNA, Long NoncodingRNA, MessengerTranscription Factorsepithelial-to-mesenchymal transition (EMT)HAND2HAND2-AS1human mesenchymal stem cells (hMSCs)mesenchymal-to-epithelial transition (MET)senescence

Identifiers

PMID38003736
PMCPMC10672054

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.