Evidence map›Paper›PMID 38003720›Full record

ArticleInternational journal of molecular sciences2023

Sedanolide Activates KEAP1-NRF2 Pathway and Ameliorates Hydrogen Peroxide-Induced Apoptotic Cell Death.

Yosuke Tabei, Hiroko Abe, Shingo Suzuki, Nobuaki Takeda, Jun-Ichiro Arai, Yoshihiro Nakajima

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yosuke TabeiHealth and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2217-14 Hayashi-cho, Takamatsu 761-0395, Kagawa, Japan.ORCID 0000-0003-0333-2716
Hiroko AbeHealth and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2217-14 Hayashi-cho, Takamatsu 761-0395, Kagawa, Japan.ORCID 0000-0003-1779-6212
Shingo SuzukiHealth and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2217-14 Hayashi-cho, Takamatsu 761-0395, Kagawa, Japan.
Nobuaki TakedaTechnology and Innovation Center, Daikin Industries, Ltd., 1-1 Nishi-Hitotsuya, Settsu 566-8585, Osaka, Japan.
Jun-Ichiro AraiTechnology and Innovation Center, Daikin Industries, Ltd., 1-1 Nishi-Hitotsuya, Settsu 566-8585, Osaka, Japan.
Yoshihiro NakajimaHealth and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2217-14 Hayashi-cho, Takamatsu 761-0395, Kagawa, Japan.ORCID 0000-0002-7422-730X
National Institute of Advanced Industrial Science and Technology · JPDaikin (Japan) · JPKagawa University · JP

Funding

Daikin Industries, Ltd.Ministry of Education, Culture, Sports, Science and Technology, Japan 21H02083
6 · The paper itself

Abstract

Sedanolide is a bioactive compound with anti-inflammatory and antitumor activities. Although it has been recently suggested that sedanolide activates the nuclear factor E2-related factor 2 (NRF2) pathway, there is little research on its effects on cellular resistance to oxidative stress. The objective of the present study was to investigate the function of sedanolide in suppressing hydrogen peroxide (H

Indexed as

Hydrogen PeroxideNF-E2-Related Factor 2AntioxidantsApoptosisBenzofuransHumansKelch-Like ECH-Associated Protein 1Oxidative StressReactive Oxygen SpeciesSignal TransductionAntioxidantsBenzofuransHydrogen PeroxideKEAP1 protein, humanKelch-Like ECH-Associated Protein 1neocnidilideNF-E2-Related Factor 2Reactive Oxygen SpeciesapoptosisARENRF2oxidative stresssedanolide

Identifiers

PMID38003720
PMCPMC10671709
OpenAlexW4388825534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.