Evidence map›Paper›PMID 38003606›Full record

SynthesisInternational journal of molecular sciences2023

Identification of 13 Novel Loci in a Genome-Wide Association Study on Taiwanese with Hepatocellular Carcinoma.

Ting-Yuan Liu, Chi-Chou Liao, Ya-Sian Chang, Yu-Chia Chen, Hong-Da Chen, I-Lu Lai, Cheng-Yuan Peng, Chin-Chun Chung, Yu-Pao Chou, Fuu-Jen Tsai and 2 more

Open access · goldAbstract readMeta-Analysis
In one paragraph

Synthesis in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ting-Yuan LiuCenter for Precision Medicine and Epigenome Research Center, China Medical University Hospital, Taichung 40447, Taiwan.ORCID 0000-0002-2729-0541
Chi-Chou LiaoCenter for Precision Medicine and Epigenome Research Center, China Medical University Hospital, Taichung 40447, Taiwan.
Ya-Sian ChangCenter for Precision Medicine and Epigenome Research Center, China Medical University Hospital, Taichung 40447, Taiwan.
Yu-Chia ChenCenter for Precision Medicine and Epigenome Research Center, China Medical University Hospital, Taichung 40447, Taiwan.
Hong-Da ChenCenter for Precision Medicine and Epigenome Research Center, China Medical University Hospital, Taichung 40447, Taiwan.ORCID 0000-0002-9330-5473
I-Lu LaiCenter for Precision Medicine and Epigenome Research Center, China Medical University Hospital, Taichung 40447, Taiwan.
Cheng-Yuan PengDepartment of Internal Medicine, Section of Hepatobiliary Tract, China Medical University Hospital, Taichung 40447, Taiwan.
Chin-Chun ChungCenter for Precision Medicine and Epigenome Research Center, China Medical University Hospital, Taichung 40447, Taiwan.
Yu-Pao ChouCenter for Precision Medicine and Epigenome Research Center, China Medical University Hospital, Taichung 40447, Taiwan.
Fuu-Jen TsaiDepartment of Medical Research, China Medical University Hospital, Taichung 40447, Taiwan.
Long-Bin JengDepartment of Surgery, Section of Hepatobiliary Tract, China Medical University Hospital, Taichung 40447, Taiwan.
Jan-Gowth ChangDepartment of Bioinformatics and Medical Engineering, Asia University, Taichung 41354, Taiwan.
China Medical University · TWAsia University · TW

Funding

China Medical University Hospital DMR-106-208China Medical University Hospital PMC-109-001
6 · The paper itself

Abstract

Liver cancer is caused by complex interactions among genetic factors, viral infection, alcohol abuse, and metabolic diseases. We conducted a genome-wide association study and polygenic risk score (PRS) model in Taiwan, employing a nonspecific etiology approach, to identify genetic risk factors for hepatocellular carcinoma (HCC). Our analysis of 2836 HCC cases and 134,549 controls revealed 13 novel associated loci such as the

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsVirus DiseasesGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansRisk Factorsbiobankchronic hepatitismeta-analysisPheWASpolygenic risk score

Identifiers

PMID38003606
PMCPMC10671380
OpenAlexW4388729878

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.