Evidence map›Paper›PMID 38003575›Full record

SynthesisInternational journal of molecular sciences2023

Immune Status of Individuals with Traumatic Spinal Cord Injury: A Systematic Review and Meta-Analysis.

Ezra Valido, Gabriela Boehl, Jörg Krebs, Jürgen Pannek, Stevan Stojic, Atanas G Atanasov, Marija Glisic, Jivko Stoyanov

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. NcRNAs: a potential treatment for spinal cord injury.Frontiers in cellular neuroscience · 2025
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Ezra ValidoSwiss Paraplegic Research, 6207 Nottwil, Switzerland.ORCID 0000-0002-2172-357X
Gabriela BoehlSwiss Paraplegic Research, 6207 Nottwil, Switzerland.ORCID 0000-0001-8504-2012
Jörg KrebsClinical Trial Unit, Swiss Paraplegic Center, 6207 Nottwil, Switzerland.
Jürgen PannekNeuro-Urology, Swiss Paraplegic Center, 6207 Nottwil, Switzerland.
Stevan StojicSwiss Paraplegic Research, 6207 Nottwil, Switzerland.
Atanas G AtanasovLudwig Boltzman Institute for Digital Health and Patient Safety, Medical University of Vienna, 1090 Vienna, Austria.
Marija GlisicSwiss Paraplegic Research, 6207 Nottwil, Switzerland.
Jivko StoyanovSwiss Paraplegic Research, 6207 Nottwil, Switzerland.ORCID 0000-0001-6842-6284
University of Bern · CHSwiss Paraplegic Research · CHInstitute of Genetics and Animal Biotechnology of the Polish Academy of Sciences · PLSwiss Paraplegic Center · CHUniversity of Lucerne · CH

Funding

European Union's Horizon 2020 research and innovation program under the Marie Skłodow-ska-Curie grant agreement 801076
6 · The paper itself

Abstract

Individuals with spinal cord injury (SCI) have higher infection rates compared to those without SCI. In this review, the immune status difference between individuals with and without traumatic SCI is investigated by examining their peripheral immune cells and markers. PubMed, Cochrane, EMBASE, and Ovid MEDLINE were searched without language or date restrictions. Studies reporting peripheral immune markers' concentration and changes in functional capabilities of immune cells that compared individuals with and without SCI were included. Studies with participants with active infection, immune disease, and central nervous system (CNS) immune markers were excluded. The review followed the PRISMA guidelines. Effect estimates were measured by Weighted Mean Difference (WMD) using a random-effects model. Study quality was assessed using the National Heart, Lung, and Blood Institute Quality Assessment Tool. Fifty-four studies (1813 with SCI and 1378 without SCI) contributed to the meta-analysis. Leukocytes (

Indexed as

Spinal Cord InjuriesBiomarkersC-Reactive ProteinFemaleHumansMaleBiomarkersC-Reactive Proteinimmune depressionimmunologymeta-analysistraumatic spinal cord injury

Identifiers

PMID38003575
PMCPMC10670917
OpenAlexW4388732679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.