Evidence map›Paper›PMID 38003562›Full record

ArticleInternational journal of molecular sciences2023

Key Genes of the Immune System and Predisposition to Acquired Hemophilia A: Evidence from a Spanish Cohort of 49 Patients Using Next-Generation Sequencing.

Jose Pardos-Gea, Laura Martin-Fernandez, Laia Closa, Ainara Ferrero, Cristina Marzo, Manuel Rubio-Rivas, Francesca Mitjavila, José Ramón González-Porras, José María Bastida, José Mateo and 7 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 1 country.

Jose Pardos-GeaSystemic Autoimmune Diseases Unit, Department of Internal Medicine, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.
Laura Martin-FernandezCongenital Coagulopathies Laboratory, Blood and Tissue Bank, 08005 Barcelona, Spain.ORCID 0000-0002-8909-508X
Laia ClosaTransfusional Medicine Group, Vall d'Hebron Research Institute, Autonomous University of Barcelona (VHIR-UAB), 08035 Barcelona, Spain.
Ainara FerreroHematology Service, Arnau de Vilanova University Hospital, 25198 Lleida, Spain.
Cristina MarzoHematology Service, Arnau de Vilanova University Hospital, 25198 Lleida, Spain.ORCID 0000-0001-6085-2158
Manuel Rubio-RivasDepartment of Internal Medicine, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), University of Barcelona, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.ORCID 0000-0002-9548-1374
Francesca MitjavilaDepartment of Internal Medicine, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), University of Barcelona, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.
José Ramón González-PorrasDepartment of Hematology, Complejo Asistencial Universitario de Salamanca (CAUSA), Instituto de Investigación Biomedica de Salamanca (IBSAL), Facultad de Medicina, Universidad de Salamanca (USAL), 37007 Salamanca, Spain.
José María BastidaDepartment of Hematology, Complejo Asistencial Universitario de Salamanca (CAUSA), Instituto de Investigación Biomedica de Salamanca (IBSAL), Facultad de Medicina, Universidad de Salamanca (USAL), 37007 Salamanca, Spain.ORCID 0000-0002-8007-3909
José MateoThrombosis and Hemostasis Unit, Sant Pau Campus Salut Barcelona, 08025 Barcelona, Spain.
Marina CarrascoThrombosis and Hemostasis Unit, Sant Pau Campus Salut Barcelona, 08025 Barcelona, Spain.ORCID 0000-0001-8301-8000
Ángel BernardoHematology Service, Central University Hospital of Asturias, 33011 Oviedo, Spain.ORCID 0000-0001-9711-8037
Itziar AstigarragaDepartment of Pediatrics, Biobizkaia Health Research Institute, Hospital Universitario Cruces, University of the Basque Country UPV/EHU, 48903 Barakaldo, Spain.ORCID 0000-0002-5012-0137
Reyes AguinacoHematology Service, University Hospital Joan XXIII, 43002 Tarragona, Spain.
Irene CorralesCongenital Coagulopathies Laboratory, Blood and Tissue Bank, 08005 Barcelona, Spain.
Iris Garcia-MartínezCongenital Coagulopathies Laboratory, Blood and Tissue Bank, 08005 Barcelona, Spain.
Francisco VidalCongenital Coagulopathies Laboratory, Blood and Tissue Bank, 08005 Barcelona, Spain.
Universitat Autònoma de Barcelona · ESBellvitge University Hospital · ESHospital de Sant Pau · ESHospital Universitari Arnau de Vilanova · ESUniversidad de Salamanca · ESHospital Universitari Joan XXIII de Tarragona · ESHospital Universitario Central de Asturias · ESUniversity of the Basque Country · ESVall d'Hebron Hospital Universitari · ES

Funding

Baxalta (United States) IIR-ESP-002171Instituto de Salud Carlos III PI18/01492
6 · The paper itself

Abstract

Acquired hemophilia A (AHA) is a rare bleeding disorder caused by the presence of autoantibodies against factor VIII (FVIII). As with other autoimmune diseases, its etiology is complex and its genetic basis is unknown. The aim of this study was to identify the immunogenetic background that predisposes individuals to AHA. HLA and KIR gene clusters, as well as

Indexed as

Hemophilia AAllelesGene FrequencyGenetic Predisposition to DiseaseGenotypeHaplotypesHigh-Throughput Nucleotide SequencingHumansImmune SystemAcquired hemophilia Aautoantibodiesgenetic predisposition to diseaseimmunogeneticsnext-generation sequencingrare bleeding disorders

Identifiers

PMID38003562
PMCPMC10671092
OpenAlexW4388694948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.