Evidence map›Paper›PMID 38003536›Full record

SynthesisInternational journal of molecular sciences2023

Interleukin Variants Are Associated with the Development and Progression of IgA Nephropathy: A Candidate-Gene Association Study and Meta-Analysis.

Ioanna Chronopoulou, Maria Tziastoudi, Georgios Pissas, Efthimios Dardiotis, Maria Dardioti, Spyridon Golfinopoulos, Georgios Filippidis, Peter R Mertens, Evangelia E Tsironi, Vassilios Liakopoulos and 2 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Ioanna ChronopoulouDepartments of Nephrology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41334 Larissa, Greece.
Maria TziastoudiDepartments of Nephrology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41334 Larissa, Greece.ORCID 0000-0002-7206-2716
Georgios PissasDepartments of Nephrology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41334 Larissa, Greece.
Efthimios DardiotisLaboratory of Neurogenetics, Department of Neurology, University of Thessaly, University Hospital of Larissa, 41334 Larissa, Greece.
Maria DardiotiLaboratory of Neurogenetics, Department of Neurology, University of Thessaly, University Hospital of Larissa, 41334 Larissa, Greece.
Spyridon GolfinopoulosDepartments of Nephrology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41334 Larissa, Greece.
Georgios FilippidisDepartments of Nephrology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41334 Larissa, Greece.
Peter R MertensUniversity Clinic for Nephrology and Hypertension, Diabetology and Endocrinology, Medical Faculty, Otto-von Guericke University Magdeburg, 39120 Magdeburg, Germany.
Evangelia E TsironiDepartment of Ophthalmology, Faculty of Medicine, School of Health Sciences, University of Thessaly, University Hospital of Larissa, 41334 Larissa, Greece.
Vassilios Liakopoulos2nd Department of Nephrology, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.ORCID 0000-0002-7564-2724
Theodoros EleftheriadisDepartments of Nephrology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41334 Larissa, Greece.ORCID 0000-0001-9302-1633
Ioannis StefanidisDepartments of Nephrology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41334 Larissa, Greece.ORCID 0000-0002-5515-8089
University of Thessaly · GRAristotle University of Thessaloniki · GRUniversity Clinic for Nephrology and Hypertension, Diabetology and Endocrinology · DE

Funding

Investigation Committee of the University Thessaly, Greece Program Nr. 2498Otto-von-Guericke University of Magdeburg, School of Medicine, Germany SFB854 TP01
6 · The paper itself

Abstract

The interleukin-1 gene cluster encodes cytokines, which modulate mesangial cell proliferation and matrix expansion, both constituting central factors in the development and progression of immunoglobulin A nephropathy (IgAN). A candidate-gene study was performed to examine the association of polymorphisms of the interleukin-1 gene cluster with the risk of progressive IgAN. To gain deeper insights into the involvement of interleukin genes in IgAN, a meta-analysis of genetic association studies (GAS) that examine the association between interleukin variants and IgAN was conducted. Association study: The case-control study consisted of 121 unrelated Caucasians with sporadic, histologically diagnosed IgAN and of 246 age- and sex-matched healthy controls. Persistent proteinuria (>2 g/24 h) and/or impaired kidney function (serum creatinine > 1.5 mg/dL) defined progressive (n = 67) vs. non-progressive (n = 54) IgAN cases. Genotypes were assessed for two promoter-region single-nucleotide polymorphisms, C-899T (rs1800587) in

Indexed as

Glomerulonephritis, IGACase-Control StudiesGenetic Predisposition to DiseaseGenotypeHumansInterleukin-1Interleukin-10Interleukin-1betaInterleukinsPolymorphism, Single NucleotideInterleukin-1Interleukin-10Interleukin-1betaInterleukinsgene polymorphismIL10IL1AIL1BIL1RNimmunoglobulin A nephropathyinterleukin-1 receptor antagonistinterleukin-1αinterleukin-1β

Identifiers

PMID38003536
PMCPMC10671103
OpenAlexW4388697742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.