Evidence map›Paper›PMID 38003490›Full record

ArticleInternational journal of molecular sciences2023

Frequency Evaluation of the

Mattia Carini, Micaela Fredi, Ilaria Cavazzana, Roberto Bresciani, Fabiana Ferrari, Eugenio Monti, Franco Franceschini, Giorgio Biasiotto

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trace Elements-Role in Joint Function and Impact on Joint Diseases.International journal of molecular sciences · 2025
    Review
  2. Special Issue "Advances in Molecular Research on Autoimmune Diseases".International journal of molecular sciences · 2024
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mattia CariniDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0001-7243-0673
Micaela FrediDepartment of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-6511-4936
Ilaria CavazzanaRheumatology and Clinical Immunology Unit, ASST Spedali Civili di Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy.
Roberto BrescianiDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-7881-7550
Fabiana FerrariPediatrics, Mother's and Baby's Health Department, Poliambulanza Foundation Hospital Insitute, 25124 Brescia, Italy.
Eugenio MontiDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-4742-7445
Franco FranceschiniDepartment of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy.
Giorgio BiasiottoDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0001-7495-7807
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITFondazione Poliambulanza Istituto Ospedaliero · ITUniversity of Brescia · IT

Funding

University of Brescia Ex60% Biasiotto
6 · The paper itself

Abstract

Autoimmune diseases are generally characterized by a multifactorial etiology and are often associated with a genetic predisposition. Both iron metabolism and the inflammatory cytokine system have been shown to play a pivotal role in the dysregulation of the immune response in many different autoimmune conditions, rheumatologic diseases included. The purpose of this work was to analyze the frequency of mutations altering the expression of IL-6 or influencing iron metabolism in patients affected by autoimmune diseases such as Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE). In this study, 144 patients were enrolled: 77 and 67 patients were affected by RA and SLE, respectively. In these cohorts, the frequency of the

Indexed as

Arthritis, RheumatoidLupus Erythematosus, SystemicCase-Control StudiesGene FrequencyGenetic Predisposition to DiseaseHemochromatosis ProteinHumansInterleukin-6IronMutationPolymorphism, Single NucleotideHemochromatosis ProteinHFE protein, humanInterleukin-6IronHFEIL-6inflammationiron metabolismrheumatoid arthritissystemic lupus erythematosus

Identifiers

PMID38003490
PMCPMC10671518
OpenAlexW4388655293

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.