Evidence map›Paper›PMID 38003488›Full record

ReviewInternational journal of molecular sciences2023

Kaempferol: A Review of Current Evidence of Its Antiviral Potential.

Argyrios Periferakis, Aristodemos-Theodoros Periferakis, Lamprini Troumpata, Konstantinos Periferakis, Andreea-Elena Scheau, Ilinca Savulescu-Fiedler, Ana Caruntu, Ioana Anca Badarau, Constantin Caruntu, Cristian Scheau

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Dentistry journal · 2026
    Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Life (Basel, Switzerland) · 2026
    Article
  13. Review
  14. Article
  15. Article
  16. Effect of Kaempferol against Biofilm Formation byRecent patents on biotechnology · 2026
    Article
  17. Kaempferol inhibits hepatitis B virus replicationFrontiers in cellular and infection microbiology · 2026
    Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Argyrios PeriferakisDepartment of Physiology, The "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0000-0002-8319-7464
Aristodemos-Theodoros PeriferakisDepartment of Physiology, The "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0000-0001-5827-3181
Lamprini TroumpataDepartment of Physiology, The "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0009-0008-7388-1466
Konstantinos PeriferakisAkadimia of Ancient Greek and Traditional Chinese Medicine, 16675 Athens, Greece.ORCID 0000-0002-8919-2840
Andreea-Elena ScheauDepartment of Radiology and Medical Imaging, Fundeni Clinical Institute, 022328 Bucharest, Romania.
Ilinca Savulescu-FiedlerDepartment of Internal Medicine, The "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Ana CaruntuDepartment of Oral and Maxillofacial Surgery, "Carol Davila" Central Military Emergency Hospital, 010825 Bucharest, Romania.ORCID 0000-0003-4200-3069
Ioana Anca BadarauDepartment of Physiology, The "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Constantin CaruntuDepartment of Physiology, The "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0000-0003-4530-7965
Cristian ScheauDepartment of Physiology, The "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0000-0001-7676-6393
Carol Davila University of Medicine and Pharmacy · ROAcademy of Athens · GRInstitutul Clinic Fundeni · ROTitu Maiorescu University · RO

Funding

Carol Davila University of Medicine and Pharmacy Publish not Perish institutional program
6 · The paper itself

Abstract

Kaempferol and its derivatives are flavonoids found in various plants, and a considerable number of these have been used in various medical applications worldwide. Kaempferol and its compounds have well-known antioxidant, anti-inflammatory and antimicrobial properties among other health benefits. However, the antiviral properties of kaempferol are notable, and there is a significant number of experimental studies on this topic. Kaempferol compounds were effective against DNA viruses such as hepatitis B virus, viruses of the alphaherpesvirinae family, African swine fever virus, and pseudorabies virus; they were also effective against RNA viruses, namely feline SARS coronavirus, dengue fever virus, Japanese encephalitis virus, influenza virus, enterovirus 71, poliovirus, respiratory syncytial virus, human immunodeficiency virus, calicivirus, and chikungunya virus. On the other hand, no effectiveness against murine norovirus and hepatitis A virus could be determined. The antiviral action mechanisms of kaempferol compounds are various, such as the inhibition of viral polymerases and of viral attachment and entry into host cells. Future research should be focused on further elucidating the antiviral properties of kaempferol compounds from different plants and assessing their potential use to complement the action of antiviral drugs.

Indexed as

African Swine Fever VirusEnterovirusRNA VirusesAnimalsAntiviral AgentsCatsHumansKaempferolsMiceSwineAntiviral AgentsKaempferolsantiviral actionsethnobotanykaempferolkaempferol derivativesphysiopathologytraditional medicine

Identifiers

PMID38003488
PMCPMC10671393
OpenAlexW4388655493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.