Evidence map›Paper›PMID 38003467›Full record

ArticleInternational journal of molecular sciences2023

Graft-Host Interaction and Its Effect on Wound Repair Using Mouse Models.

Nicole Garcia, Md Mostafizur Rahman, Carlos Luis Arellano, Ilia Banakh, Chen Yung-Chih, Karlheinz Peter, Heather Cleland, Cheng Hean Lo, Shiva Akbarzadeh

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Nicole GarciaSkin Bioengineering Laboratory, Victorian Adult Burns Service, Alfred Health, 89 Commercial Road, Melbourne, VIC 3004, Australia.
Md Mostafizur RahmanSkin Bioengineering Laboratory, Victorian Adult Burns Service, Alfred Health, 89 Commercial Road, Melbourne, VIC 3004, Australia.ORCID 0009-0008-9891-720X
Carlos Luis ArellanoSkin Bioengineering Laboratory, Victorian Adult Burns Service, Alfred Health, 89 Commercial Road, Melbourne, VIC 3004, Australia.
Ilia BanakhSkin Bioengineering Laboratory, Victorian Adult Burns Service, Alfred Health, 89 Commercial Road, Melbourne, VIC 3004, Australia.
Chen Yung-ChihAtherothrombosis and Vascular, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.
Karlheinz PeterAtherothrombosis and Vascular, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.ORCID 0000-0002-8040-2258
Heather ClelandSkin Bioengineering Laboratory, Victorian Adult Burns Service, Alfred Health, 89 Commercial Road, Melbourne, VIC 3004, Australia.
Cheng Hean LoSkin Bioengineering Laboratory, Victorian Adult Burns Service, Alfred Health, 89 Commercial Road, Melbourne, VIC 3004, Australia.ORCID 0000-0002-1386-5332
Shiva AkbarzadehSkin Bioengineering Laboratory, Victorian Adult Burns Service, Alfred Health, 89 Commercial Road, Melbourne, VIC 3004, Australia.ORCID 0000-0002-2787-3317
Alfred Health · AUBaker Heart and Diabetes Institute · AU

Funding

The Alfred Hospital N/A
6 · The paper itself

Abstract

Autologous skin grafting has been commonly used in clinics for decades to close large wounds, yet the cellular and molecular interactions between the wound bed and the graft that mediates the wound repair are not fully understood. The aim of this study was to better understand the molecular changes in the wound triggered by autologous and synthetic grafting. Defining the wound changes at the molecular level during grafting sets the basis to test other engineered skin grafts by design. In this study, a full-thickness skin graft (SKH-1 hairless) mouse model was established. An autologous full-thickness skin graft (FTSG) or an acellular fully synthetic Biodegradable Temporising Matrix (BTM) was grafted. The wound bed/grafts were analysed at histological, RNA, and protein levels during the inflammation (day 1), proliferation (day 5), and remodelling (day 21) phases of wound repair. The results showed that in this mouse model, similar to others, inflammatory marker levels, including

Indexed as

Skin, ArtificialWound HealingAnimalsDisease Models, AnimalMiceSkinSkin TransplantationTransforming Growth Factor beta1Transforming Growth Factor beta1IL-6myofibroblastskin graftingTGF-β1wound repair

Identifiers

PMID38003467
PMCPMC10671506
OpenAlexW4388668722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.