Evidence map›Paper›PMID 38003404›Full record

ArticleInternational journal of molecular sciences2023

Increase in hnRNPA1 Expression Suffices to Kill Motor Neurons in Transgenic Rats.

Bo Huang, Xionghao Liu, Tingting Zhang, Qinxue Wu, Cao Huang, Xu-Gang Xia, Hongxia Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Bo HuangDepartment of Pathology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA.ORCID 0000-0002-3028-1945
Xionghao LiuDepartment of Pathology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA.ORCID 0000-0002-2633-7096
Tingting ZhangDepartment of Environmental Health Sciences, Robert Stempel College of Public Health & Social Work, The Center for Translational Sciences, Florida International University, Port St. Lucie, FL 34987, USA.
Qinxue WuDepartment of Pathology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA.
Cao HuangDepartment of Pathology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA.ORCID 0000-0001-7033-2498
Xu-Gang XiaDepartment of Environmental Health Sciences, Robert Stempel College of Public Health & Social Work, The Center for Translational Sciences, Florida International University, Port St. Lucie, FL 34987, USA.
Hongxia ZhouDepartment of Environmental Health Sciences, Robert Stempel College of Public Health & Social Work, The Center for Translational Sciences, Florida International University, Port St. Lucie, FL 34987, USA.
Thomas Jefferson University · USFlorida International University · US

Funding

Study on PFN1 Pathobiology Using Rat ModelsR01NS110455 · NINDS · UNIVERSITY OF CENTRAL FLORIDA · PI XIA, XUGANG, ZHOU, HONGXIA · 2019 to 2023
$3.0M
Redesign Rat Model for ALS ResearchR01NS089701 · NINDS · UNIVERSITY OF CENTRAL FLORIDA · PI XIA, XUGANG, ZHOU, HONGXIA · 2014 to 2018
$1.7M
Study on hnRNPA1 Pathobiology in ALSR01NS095962 · NINDS · UNIVERSITY OF CENTRAL FLORIDA · PI XIA, XUGANG · 2016 to 2020
$1.6M
NINDS NIH HHS NS089701, NS095962, NS110455NINDS NIH HHS R01 NS089701NINDS NIH HHS R01 NS095962NINDS NIH HHS R01 NS110455
6 · The paper itself

Abstract

A dominant mutation in hnRNPA1 causes amyotrophic lateral sclerosis (ALS), but it is not known whether this mutation leads to motor neuron death through increased or decreased function. To elucidate the relationship between pathogenic hnRNPA1 mutation and its native function, we created novel transgenic rats that overexpressed wildtype rat hnRNPA1 exclusively in motor neurons. This targeted expression of wildtype hnRNPA1 caused severe motor neuron loss and subsequent denervation muscle atrophy in transgenic rats that recapitulated the characteristics of ALS. These findings demonstrate that the augmentation of hnRNPA1 expression suffices to trigger motor neuron degeneration and the manifestation of ALS-like phenotypes. It is reasonable to infer that an amplification of an as-yet undetermined hnRNPA1 function plays a pivotal role in the pathogenesis of familial ALS caused by pathogenic hnRNPA1 mutation.

Indexed as

Amyotrophic Lateral SclerosisAnimalsDisease Models, AnimalMiceMice, TransgenicMotor NeuronsMutationPhenotypeRatsRats, TransgenicSuperoxide Dismutase-1Superoxide Dismutase-1ALShnRNPA1motor neuron diseaseratstransgenic rodents

Identifiers

PMID38003404
PMCPMC10671660
OpenAlexW4388636942

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.