Evidence map›Paper›PMID 38003342›Full record

ArticleInternational journal of molecular sciences2023

Synergic Action of Systemic Risedronate and Local Rutherpy in Peri-implantar Repair of Ovariectomized Rats: Biomechanical and Molecular Analysis.

Bruna Kaori Namba Inoue, Laura Vidoto Paludetto, Naara Gabriela Monteiro, Fábio Roberto de Souza Batista, Igor Lebedenco Kitagawa, Roberto Santana da Silva, Cristina Antoniali, Paulo Noronha Lisboa Filho, Roberta Okamoto

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Protective Effects ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bruna Kaori Namba InoueDepartment of Basic Sciences, Araçatuba Dental School, São Paulo State University Júlio de Mesquita Filho-UNESP, Aracatuba 16015-050, SP, Brazil.
Laura Vidoto PaludettoDepartment of Basic Sciences, Araçatuba Dental School, São Paulo State University Júlio de Mesquita Filho-UNESP, Aracatuba 16015-050, SP, Brazil.ORCID 0000-0001-6251-8604
Naara Gabriela MonteiroDepartment of Basic Sciences, Araçatuba Dental School, São Paulo State University Júlio de Mesquita Filho-UNESP, Aracatuba 16015-050, SP, Brazil.ORCID 0000-0002-2857-9195
Fábio Roberto de Souza BatistaDepartment of Basic Sciences, Araçatuba Dental School, São Paulo State University Júlio de Mesquita Filho-UNESP, Aracatuba 16015-050, SP, Brazil.
Igor Lebedenco KitagawaFederal Institute of Education, Science and Technology of São Paulo (IFSP), Birigui 16201-407, SP, Brazil.
Roberto Santana da SilvaDepartment of Biomolecular Sciences, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo-USP, Ribeirão Preto 14040-403, SP, Brazil.ORCID 0000-0002-0430-2255
Cristina AntonialiDepartment of Basic Sciences, Araçatuba Dental School, São Paulo State University Júlio de Mesquita Filho-UNESP, Aracatuba 16015-050, SP, Brazil.ORCID 0000-0002-0315-6161
Paulo Noronha Lisboa FilhoDepartment of Physics and Meteorology, Bauru Sciences School, São Paulo State University Júlio de Mesquita Filho-UNESP, Bauru 17033-360, SP, Brazil.ORCID 0000-0002-7734-4069
Roberta OkamotoDepartment of Basic Sciences, Araçatuba Dental School, São Paulo State University Júlio de Mesquita Filho-UNESP, Aracatuba 16015-050, SP, Brazil.ORCID 0000-0002-6773-6966

Funding

São Paulo Research Foundation 2020/10462-5
6 · The paper itself

Abstract

Postmenopausal osteoporosis and poor dietary habits can lead to overweightness and obesity. Bisphosphonates are the first-line treatment for osteoporosis. However, some studies show that they may increase the risk of osteonecrosis of the jaw. Considering the antimicrobial, angiogenic and vasodilatory potential of nitric oxide, this study aims to evaluate the local activity of this substance during the placement of surface-treated implants. Seventy-two Wistar rats were divided into three groups: SHAM (SHAM surgery), OVX + HD (ovariectomy + cafeteria diet), and OVX + HD + RIS (ovariectomy + cafeteria diet + sodium risedronate treatment), which were further subdivided according to the surface treatment of the future implant: CONV (conventional), TE10, or TE100 (TERPY at 10 or 100 μM concentration);

Indexed as

Bone DensityOsteoporosisAnimalsFemaleHumansOvariectomyRatsRats, WistarRisedronic AcidVascular Endothelial Growth Factor ARisedronic AcidVascular Endothelial Growth Factor Abisphosphonateshigh-fat dietnitric oxide donorosteoporosis

Identifiers

PMID38003342
PMCPMC10671386

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.