Evidence map›Paper›PMID 38003293›Full record

ArticleInternational journal of molecular sciences2023

Association of

Montserrat Justo-Garrido, Alejandro López-Saavedra, Nicolás Alcaraz, Carlo C Cortés-González, Luis F Oñate-Ocaña, Claudia Haydee Sarai Caro-Sánchez, Clementina Castro-Hernández, Cristian Arriaga-Canon, José Díaz-Chávez, Luis A Herrera

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Montserrat Justo-GarridoCancer Research Unit, Institute of Biomedical Research, National Autonomous University of Mexico (UNAM)-National Institute of Cancerology, San Fernando Av #22, XVI Section, Mexico City 14080, Mexico.ORCID 0000-0002-1093-1031
Alejandro López-SaavedraCancer Research Unit, Institute of Biomedical Research, National Autonomous University of Mexico (UNAM)-National Institute of Cancerology, San Fernando Av #22, XVI Section, Mexico City 14080, Mexico.ORCID 0000-0002-3838-4738
Nicolás AlcarazThe Bioinformatics Centre, Department of Biology, University of Copenhagen, 2200 Copenhagen, Denmark.
Carlo C Cortés-GonzálezCancer Research Unit, Institute of Biomedical Research, National Autonomous University of Mexico (UNAM)-National Institute of Cancerology, San Fernando Av #22, XVI Section, Mexico City 14080, Mexico.ORCID 0000-0001-5516-6081
Luis F Oñate-OcañaDepartment of Gastroenterology, National Cancer Institute (INCan), Tlalpan, Mexico City 14080, Mexico.ORCID 0000-0002-2020-0283
Claudia Haydee Sarai Caro-SánchezMolecular Pathology and Immunology, National Cancer Institute (INCan), Tlalpan, Mexico City 14080, Mexico.
Clementina Castro-HernándezCancer Research Unit, Institute of Biomedical Research, National Autonomous University of Mexico (UNAM)-National Institute of Cancerology, San Fernando Av #22, XVI Section, Mexico City 14080, Mexico.ORCID 0000-0002-5641-3627
Cristian Arriaga-CanonCancer Research Unit, Institute of Biomedical Research, National Autonomous University of Mexico (UNAM)-National Institute of Cancerology, San Fernando Av #22, XVI Section, Mexico City 14080, Mexico.
José Díaz-ChávezCancer Research Unit, Institute of Biomedical Research, National Autonomous University of Mexico (UNAM)-National Institute of Cancerology, San Fernando Av #22, XVI Section, Mexico City 14080, Mexico.ORCID 0000-0001-9583-3790
Luis A HerreraCancer Research Unit, Institute of Biomedical Research, National Autonomous University of Mexico (UNAM)-National Institute of Cancerology, San Fernando Av #22, XVI Section, Mexico City 14080, Mexico.ORCID 0000-0003-3998-9306
Instituto Nacional de Cancerología · MXUniversity of Copenhagen · DK

Funding

Universidad Nacional Autónoma de México PAPIIT IN208815
6 · The paper itself

Abstract

Chemoresistance to standard neoadjuvant treatment commonly occurs in locally advanced breast cancer, particularly in the luminal subtype, which is hormone receptor-positive and represents the most common subtype of breast cancer associated with the worst outcomes. Identifying the genes associated with chemoresistance is crucial for understanding the underlying mechanisms and discovering effective treatments. In this study, we aimed to identify genes linked to neoadjuvant chemotherapy resistance in 62 retrospectively included patients with luminal breast cancer. Whole RNA sequencing of 12 patient biopsies revealed 269 differentially expressed genes in chemoresistant patients. We further validated eight highly correlated genes associated with resistance. Among these, solute carrier family 12 member 1 (

Indexed as

Breast NeoplasmsDrug Resistance, NeoplasmFemaleHumansMembrane Transport ProteinsNeoadjuvant TherapyReceptors, AMPARetrospective StudiesSolute Carrier Family 12, Member 1glutamate receptor ionotropic, AMPA 4Membrane Transport ProteinsReceptors, AMPASLC12A1 protein, humanSolute Carrier Family 12, Member 1chemoresistanceion transportlocally advancedluminal breast cancerneoadjuvant chemotherapy

Identifiers

PMID38003293
PMCPMC10670992
OpenAlexW4388534817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.