Evidence map›Paper›PMID 38003281›Full record

ArticleInternational journal of molecular sciences2023

The Effect of Ficin Immobilized on Carboxymethyl Chitosan on Biofilms of Oral Pathogens.

Diana R Baidamshina, Elena Yu Trizna, Svetlana S Goncharova, Andrey V Sorokin, Maria S Lavlinskaya, Anastasia P Melnik, Leysan F Gafarova, Maya A Kharitonova, Olga V Ostolopovskaya, Valeriy G Artyukhov and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Diana R BaidamshinaInstitute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia.
Elena Yu TriznaInstitute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia.ORCID 0000-0002-9881-0559
Svetlana S GoncharovaDepartment of Biophysics and Biotechnology, Voronezh State University, 394018 Voronezh, Russia.
Andrey V SorokinDepartment of Biophysics and Biotechnology, Voronezh State University, 394018 Voronezh, Russia.ORCID 0000-0001-5268-9557
Maria S LavlinskayaDepartment of Biophysics and Biotechnology, Voronezh State University, 394018 Voronezh, Russia.ORCID 0000-0001-9058-027X
Anastasia P MelnikInstitute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia.ORCID 0009-0005-4179-6919
Leysan F GafarovaInstitute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia.
Maya A KharitonovaInstitute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia.ORCID 0000-0001-6467-1688
Olga V OstolopovskayaInstitute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia.
Valeriy G ArtyukhovDepartment of Biophysics and Biotechnology, Voronezh State University, 394018 Voronezh, Russia.
Evgenia A SokolovaInstitute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia.ORCID 0000-0002-6726-3513
Marina G HolyavkaDepartment of Biophysics and Biotechnology, Voronezh State University, 394018 Voronezh, Russia.ORCID 0000-0002-1390-4119
Mikhail I BogachevBiomedical Engineering Research Centre, St. Petersburg Electrotechnical University, 197022 St. Petersburg, Russia.ORCID 0000-0002-0356-5651
Airat R KayumovInstitute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia.ORCID 0000-0001-7195-1557
Pavel V ZelenikhinInstitute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia.ORCID 0000-0003-1971-1745
Kazan Federal University · RUMarine Hydrophysical Institute · RUVoronezh State University · RUSaint Petersburg State Electrotechnical University · RU

Funding

Russian Science Foundation RSF-21-74-20053Subsidy allocated to Kazan Federal University for the state assignment in the sphere of scientific activities Project No. FZSM-2022-0017
6 · The paper itself

Abstract

In the last decade, Ficin, a proteolytic enzyme extracted from the latex sap of the wild fig tree, has been widely investigated as a promising tool for the treatment of microbial biofilms, wound healing, and oral care. Here we report the antibiofilm properties of the enzyme immobilized on soluble carboxymethyl chitosan (CMCh) and CMCh itself. Ficin was immobilized on CMCh with molecular weights of either 200, 350 or 600 kDa. Among them, the carrier with a molecular weight of 200 kDa bound the maximum amount of enzyme, binding up to 49% of the total protein compared to 19-32% of the total protein bound to other CMChs. Treatment with pure CMCh led to the destruction of biofilms formed by

Indexed as

ChitosanFicainBiofilmsChlorhexidineHumansStreptococcus gordoniiStreptococcus mutansChitosanChlorhexidineFicainbacterial biofilmscarboxymethyl chitosanficinoral microbiota

Identifiers

PMID38003281
PMCPMC10671066
OpenAlexW4388538316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.