Evidence map›Paper›PMID 38003242›Full record

Observational studyInternational journal of molecular sciences2023

Seasonal Azithromycin Use in Paediatric Protracted Bacterial Bronchitis Does Not Promote Antimicrobial Resistance but Does Modulate the Nasopharyngeal Microbiome.

Simon J Hardman, Fiona M Shackley, Kelechi Ugonna, Thomas C Darton, Alan S Rigby, Debby Bogaert, Justyna M Binkowska, Alison M Condliffe

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Simon J HardmanDepartment of General Paediatrics, Chesterfield Royal Hospital NHS Foundation Trust, Chesterfield S44 5BL, UK.
Fiona M ShackleyDepartment of Paediatric Immunology, Allergy and Infectious Diseases, Sheffield Children's Hospital NHS Foundation Trust, Sheffield S10 2TH, UK.
Kelechi UgonnaDepartment of Paediatric Respiratory Medicine, Sheffield Children's Hospital NHS Foundation Trust, Sheffield S10 2TH, UK.
Thomas C DartonDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield S10 2RX, UK.
Alan S RigbyHull York Medical School, University of Hull, Hull HU6 7RX, UK.
Debby BogaertDepartment of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Justyna M BinkowskaCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh EH8 9YL, UK.
Alison M CondliffeDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield S10 2RX, UK.
Sheffield Children's Hospital · GBUniversity of Sheffield · GBCentre for Inflammation Research · GBChesterfield Royal Hospital NHS Foundation Trust · GBUniversity Medical Center Utrecht · NLUniversity of Hull · GB

Funding

Antibiotic Research UK ANTSRG 03/2018Bassetlaw Fellowship Scheme 50059609Florey Institute AMR Research Capital Funding NIHR200636Sir Halley Stewart Trust 1589
6 · The paper itself

Abstract

Protracted bacterial bronchitis (PBB) causes chronic wet cough for which seasonal azithromycin is increasingly used to reduce exacerbations. We investigated the impact of seasonal azithromycin on antimicrobial resistance and the nasopharyngeal microbiome. In an observational cohort study, 50 children with PBB were enrolled over two consecutive winters; 25/50 at study entry were designated on clinical grounds to take azithromycin over the winter months and 25/50 were not. Serial nasopharyngeal swabs were collected during the study period (12-20 months) and cultured bacterial isolates were assessed for antimicrobial susceptibility. 16S rRNA-based sequencing was performed on a subset of samples. Irrespective of azithromycin usage, high levels of azithromycin resistance were found; 73% of bacteria from swabs in the azithromycin group vs. 69% in the comparison group. Resistance was predominantly driven by azithromycin-resistant

Indexed as

Bacterial InfectionsBronchitis, ChronicMicrobiotaAnti-Bacterial AgentsAzithromycinBacteriaChildChronic DiseaseCoughDrug Resistance, BacterialErythromycinHumansRNA, Ribosomal, 16SSeasonsStreptococcus pneumoniaeAnti-Bacterial AgentsAzithromycinErythromycinRNA, Ribosomal, 16Santimicrobial resistanceazithromycinmicrobiomepaediatricsprotracted bacterial bronchitis

Identifiers

PMID38003242
PMCPMC10671346
OpenAlexW4388446669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.