Evidence map›Paper›PMID 38003225›Full record

ArticleInternational journal of molecular sciences2023

Development of Apoptotic-Cell-Inspired Antibody-Drug Conjugate for Effective Immune Modulation.

Gyeongwoo Lee, Taishu Iwase, Shunsuke Matsumoto, Ahmed Nabil, Mitsuhiro Ebara

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Molecular Insights into Macromolecules Structure, Function, and Regulation.International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Gyeongwoo LeeResearch Center for Macromolecules and Biomaterials, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, Japan.
Taishu IwaseResearch Center for Macromolecules and Biomaterials, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, Japan.
Shunsuke MatsumotoResearch Center for Macromolecules and Biomaterials, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, Japan.
Ahmed NabilResearch Center for Macromolecules and Biomaterials, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, Japan.ORCID 0000-0002-5617-4726
Mitsuhiro EbaraResearch Center for Macromolecules and Biomaterials, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, Japan.ORCID 0000-0002-7906-0350
University of Tsukuba · JPBeni-Suef University · EG

Funding

Japan Science and Technology Agency creation of science and technology innovation, Grant Number JPMJFS2106Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research (B) (JP19H04476)Japan Society for the Promotion of Science Grant-in-Aid for Transformative Research Areas (A) (JP20H05877)
6 · The paper itself

Abstract

backgroundApoptotic cells' phosphoserine (PS) groups have a significant immunosuppressive effect. They inhibit proinflammatory signals by interacting with various immune cells, including macrophages, dendritic cells, and CD4

aimWe conducted this research to introduce an apoptotic-cell-inspired antibody-drug conjugate for effective immunomodulation.

methodPoly(2-hydroxyethyl methacrylate-

resultsWe successfully synthesized ADCs with a significant anti-inflammatory effect and optimized the antibody-polymer ratio to achieve the highest antibody-binding affinity.

conclusionWe successfully introduced p(HEMA-

Indexed as

ImmunoconjugatesAnti-Inflammatory AgentsImmunoglobulin GMethacrylatesPolymersAnti-Inflammatory Agentshydroxyethyl methacrylateImmunoconjugatesImmunoglobulin GMethacrylatesPolymersantibody–drug conjugatesantibody–polymer conjugatesbio-inspired polymerimmune modulation

Identifiers

PMID38003225
PMCPMC10671176
OpenAlexW4388445646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.