Evidence map›Paper›PMID 38003044›Full record

ArticleGenes2023

Transcriptomic Landscape of Circulating Extracellular Vesicles in Heart Transplant Ischemia-Reperfusion.

SeoJeong Joo, Kishor Dhaygude, Sofie Westerberg, Rainer Krebs, Maija Puhka, Emil Holmström, Simo Syrjälä, Antti I Nykänen, Karl Lemström

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Extracellular Vesicles and Immune Activation in Solid Organ Transplantation: The Impact of Immunosuppression.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

SeoJeong JooTranslational Immunology Research Program, Transplantation Laboratory, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0003-2214-3523
Kishor DhaygudeTranslational Immunology Research Program, Transplantation Laboratory, University of Helsinki, 00014 Helsinki, Finland.
Sofie WesterbergTranslational Immunology Research Program, Transplantation Laboratory, University of Helsinki, 00014 Helsinki, Finland.
Rainer KrebsTranslational Immunology Research Program, Transplantation Laboratory, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0003-0418-8226
Maija PuhkaInstitute for Molecular Medicine Finland FIMM, EV and HiPREP Core, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0002-6445-1017
Emil HolmströmTranslational Immunology Research Program, Transplantation Laboratory, University of Helsinki, 00014 Helsinki, Finland.
Simo SyrjäläTranslational Immunology Research Program, Transplantation Laboratory, University of Helsinki, 00014 Helsinki, Finland.
Antti I NykänenTranslational Immunology Research Program, Transplantation Laboratory, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0003-3027-2309
Karl LemströmTranslational Immunology Research Program, Transplantation Laboratory, University of Helsinki, 00014 Helsinki, Finland.
University of Helsinki · FI

Funding

Aarne Koskelon SäätiöAcademy of FinlandEmil Aaltosen SäätiöFinnish Cultural FoundationFinnish Foundation for Cardiovascular ResearchFinnish Society of AngiologyFinnish Transplantation SocietyHelsinki University HospitalIda Montinin SäätiöJane and Aatos Erkko FoundationMaud Kuistila Memorial FoundationPaavo Ilmari Ahvenainen FoundationPäivikki and Sakari Sohlberg FoundationPaulo FoundationResearch and Science Foundation of FarmosSigrid Jusélius FoundationSirpa and Markku Jalkanen FoundationUniversity of Helsinki
6 · The paper itself

Abstract

Ischemia-reperfusion injury (IRI) is an inevitable event during heart transplantation, which is known to exacerbate damage to the allograft. However, the precise mechanisms underlying IRI remain incompletely understood. Here, we profiled the whole transcriptome of plasma extracellular vesicles (EVs) by RNA sequencing from 41 heart transplant recipients immediately before and at 12 h after transplant reperfusion. We found that the expression of 1317 protein-coding genes in plasma EVs was changed at 12 h after reperfusion. Upregulated genes of plasma EVs were related to metabolism and immune activation, while downregulated genes were related to cell survival and extracellular matrix organization. In addition, we performed correlation analyses between EV transcriptome and intensity of graft IRI (i.e., cardiomyocyte injury), as well as EV transcriptome and primary graft dysfunction, as well as any biopsy-proven acute rejection after heart transplantation. We ultimately revealed that at 12 h after reperfusion, 4 plasma EV genes (

Indexed as

Extracellular VesiclesHeart TransplantationPrimary Graft DysfunctionReperfusion InjuryHumansIschemiaReperfusionTranscriptomeexosomesextracellular vesiclesheart transplantationischemia–reperfusion injuryplasmaprimary graft dysfunctionRNA sequencing

Identifiers

PMID38003044
PMCPMC10671425
OpenAlexW4388795306

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.