Evidence map›Paper›PMID 38002962›Full record

ArticleGenes2023

Genome-Wide Association Study of Beta-Blocker Survival Benefit in Black and White Patients with Heart Failure with Reduced Ejection Fraction.

Jasmine A Luzum, Alessandra M Campos-Staffico, Jia Li, Ruicong She, Hongsheng Gui, Edward L Peterson, Bin Liu, Hani N Sabbah, Mark P Donahue, William E Kraus and 2 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jasmine A LuzumDepartment of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI 48109, USA.ORCID 0000-0003-3639-717X
Alessandra M Campos-StafficoDepartment of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI 48109, USA.ORCID 0000-0003-4172-7524
Jia LiDepartment of Public Health Sciences, Henry Ford Health System, Detroit, MI 48202, USA.
Ruicong SheDepartment of Public Health Sciences, Henry Ford Health System, Detroit, MI 48202, USA.
Hongsheng GuiCenter for Individualized and Genomic Medicine Research (CIGMA), Henry Ford Health System, Detroit, MI 48202, USA.
Edward L PetersonDepartment of Public Health Sciences, Henry Ford Health System, Detroit, MI 48202, USA.
Bin LiuDepartment of Public Health Sciences, Henry Ford Health System, Detroit, MI 48202, USA.
Hani N SabbahHeart and Vascular Institute, Henry Ford Health System, Detroit, MI 48202, USA.
Mark P DonahueSchool of Medicine, Duke University, Durham, NC 27710, USA.
William E KrausSchool of Medicine, Duke University, Durham, NC 27710, USA.
L Keoki WilliamsCenter for Individualized and Genomic Medicine Research (CIGMA), Henry Ford Health System, Detroit, MI 48202, USA.
David E LanfearCenter for Individualized and Genomic Medicine Research (CIGMA), Henry Ford Health System, Detroit, MI 48202, USA.

Funding

ACHIEVE P3 - CHDP50MD017351 · NIMHD · WAYNE STATE UNIVERSITY · PI LEVY, PHILLIP DAVID · 2021 to 2025
$21.1M
Substrate Selection and Oxidative Stress in Heart FailureP01HL074237 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI RECCHIA, FABIO A · 2003 to 2013
$19.9M
PHARMACOGENOMICS OF INHALED CORTICOSTEROID RESPONSIVENESS IN PATIENTS WITH ASTHMAR01AI079139 · NIAID · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2009 to 2013
$3.9M
Impact of Race and Genetic Factors on Beta-blocker Effectiveness in Heart FailureR01HL103871 · NHLBI · HENRY FORD HEALTH SYSTEM · PI LANFEAR, DAVID E · 2011 to 2015
$3.5M
Leveraging electronic medical records to perform large-scale diabetes pharmacogenomics among ancestrally diverse patient populationsR01DK113003 · NIDDK · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2017 to 2021
$3.2M
Plasma Metabolomics and Myocardial Energetics in Heart FailureR01HL132154 · NHLBI · HENRY FORD HEALTH SYSTEM · PI LANFEAR, DAVID E, SABBAH, HANI N · 2017 to 2020
$3.1M
Poly-omic Study of Asthma Exacerbations in Diverse PopulationsR01HL141845 · NHLBI · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2019 to 2022
$3.0M
Combined Transcriptomics and Genomics to Find Asthma Genes in Admixed PopulationsR01HL118267 · NHLBI · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2014 to 2017
$2.9M
VALIDATION OF ADHERENCE DATA--USE IN CLINICAL PRACTICER01DK064695 · NIDDK · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2003 to 2010
$2.7M
Precision Medicine for Heart Failure: The Role of Genomics in the Efficacy and Racial Disparity of Cornerstone PharmacotherapyK08HL146990 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUZUM, JASMINE A · 2019 to 2023
$772k
Bleeding on Direct Oral Anticoagulants: Identification of Genetic Risk Factors and a Polygenic Predictive Score in Patients with Atrial FibrillationF32HL162231 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CAMPOS STAFFICO, ALESSANDRA MENEZES · 2022 to 2022
$79k
NHLBI NIH HHS F32 HL162231NHLBI NIH HHS K08 HL146990NHLBI NIH HHS L30 HL110279NHLBI NIH HHS P01 HL074237NHLBI NIH HHS R01 HL103871NHLBI NIH HHS R01 HL118267NHLBI NIH HHS R01 HL132154NHLBI NIH HHS R01 HL141845NIAID NIH HHS R01 AI079139NIDDK NIH HHS R01 DK064695NIDDK NIH HHS R01 DK113003NIH HHS F32HL162231NIH HHS K08HL146990NIH HHS L30HL110279NIH HHS P01HL074237NIH HHS P50MD017351NIH HHS R01AI079139NIH HHS R01DK064695NIH HHS R01DK113003NIH HHS R01HL118267NIH HHS R01HL132154NIH HHS R01HL141845NIMHD NIH HHS P50 MD017351
6 · The paper itself

Abstract

In patients with heart failure with reduced ejection fraction (HFrEF), individual responses to beta-blockers vary. Candidate gene pharmacogenetic studies yielded significant but inconsistent results, and they may have missed important associations. Our objective was to use an unbiased genome-wide association study (GWAS) to identify loci influencing beta-blocker survival benefit in HFrEF patients. Genetic variant × beta-blocker exposure interactions were tested in Cox proportional hazards models for all-cause mortality stratified by self-identified race. The models were adjusted for clinical risk factors and propensity scores. A prospective HFrEF registry (469 black and 459 white patients) was used for discovery, and linkage disequilibrium (LD) clumped variants with a beta-blocker interaction of

Indexed as

Adrenergic beta-AntagonistsHeart FailureVentricular Dysfunction, LeftBlack or African AmericanGenome-Wide Association StudyHumansProspective StudiesStroke VolumeWhiteAdrenergic beta-Antagonistsbeta-blockergenome-wide association studyheart failure with reduced ejection fractionsurvival

Identifiers

PMID38002962
PMCPMC10671316

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.