Evidence map›Paper›PMID 38002960›Full record

ArticleGenes2023

Homologous Recombination and Repair Functions Required for Mutagenicity during Yeast Meiosis.

Liat Morciano, Renana M Elgrabli, Drora Zenvirth, Ayelet Arbel-Eden

Open access · goldAbstract read
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 69% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Liat MorcianoDepartment of Genetics, Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Renana M ElgrabliDepartment of Genetics, Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Drora ZenvirthDepartment of Genetics, Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Ayelet Arbel-EdenDepartment of Genetics, Hebrew University of Jerusalem, Jerusalem 91904, Israel.ORCID 0000-0001-6630-0805
Hebrew University of Jerusalem · IL

Funding

Israel Science Foundation Grant # 397/20Israel Science Foundation Grant # 501/16
6 · The paper itself

Abstract

Several meiotic events reshape the genome prior to its transfer (via gametes) to the next generation. The occurrence of new meiotic mutations is tightly linked to homologous recombination (HR) and firmly depends on Spo11-induced DNA breaks. To gain insight into the molecular mechanisms governing mutagenicity during meiosis, we examined the timing of mutation and recombination events in cells deficient in various DNA HR-repair genes, which represent distinct functions along the meiotic recombination process. Despite sequence similarities and overlapping activities of the two DNA translocases, Rad54 and Tid1, we observed essential differences in their roles in meiotic mutation occurrence: in the absence of Rad54, meiotic mutagenicity was elevated 8-fold compared to the wild type (WT), while in the

Indexed as

Saccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsDNADNA, Single-StrandedHomologous RecombinationMeiosisMutagensDNADNA, Single-StrandedMutagensSaccharomyces cerevisiae ProteinsDNA double-strand breaks (DSBs)DNA repairhomologous recombinationmeiosismutations

Identifiers

PMID38002960
PMCPMC10671739
OpenAlexW4388095020

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.