Evidence map›Paper›PMID 38002862›Full record

ArticleChildren (Basel, Switzerland)2023

Laparoscopic Cholecystectomy in Children: The Experience of Two Centers Focusing on Indications and Timing in the Era of "New Technologies".

Francesca Destro, Ugo Maria Pierucci, Eleonora Durante, Anna Maria Caruso, Vincenza Girgenti, Carlotta Paola Maria Canonica, Irene Degrassi, Alessandro Campari, Alessandro Pellegrinelli, Marta Barisella and 5 more

Open access · goldAbstract read
In one paragraph

Article in Children (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Cholecystectomy in Children: Indications and Timing.Children (Basel, Switzerland) · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Francesca DestroDepartment of Pediatric Surgery, Buzzi Children's Hospital, 20154 Milan, Italy.ORCID 0000-0002-0206-2892
Ugo Maria PierucciDepartment of Pediatric Surgery, Buzzi Children's Hospital, 20154 Milan, Italy.
Eleonora DuranteDepartment of Pediatric Surgery, Buzzi Children's Hospital, 20154 Milan, Italy.
Anna Maria CarusoPediatric Surgery Unit, Children's Hospital, ARNAS Civico-Di Cristina-Benfratelli, 90127 Palermo, Italy.
Vincenza GirgentiPediatric Surgery Unit, Children's Hospital, ARNAS Civico-Di Cristina-Benfratelli, 90127 Palermo, Italy.
Carlotta Paola Maria CanonicaDepartment of Pediatric Surgery, Buzzi Children's Hospital, 20154 Milan, Italy.
Irene DegrassiDepartment of Pediatrics, Buzzi Children's Hospital, University of Milan, 20154 Milan, Italy.ORCID 0000-0002-8123-7522
Alessandro CampariDepartment of Pediatric Radiology, Buzzi Children's Hospital, 20154 Milan, Italy.
Alessandro PellegrinelliPathology Unit, Department of Biomedical and Clinical Sciences, University of Milan, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.
Marta BarisellaPathology Unit, Department of Biomedical and Clinical Sciences, University of Milan, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.
Manuela NebuloniPathology Unit, Department of Biomedical and Clinical Sciences, University of Milan, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.
Marco BruneroDepartment of Pediatric Surgery, Buzzi Children's Hospital, 20154 Milan, Italy.
Elia Mario BiganzoliDepartment of Biomedical and Clinical Sciences (DIBIC) & Data Science Research Center (DSRC), Unit of Clinical Research and Medical Statistics, Ospedale "L. Sacco" LITA Campus, University of Milan, 20122 Milan, Italy.ORCID 0000-0003-1202-5873
Valeria CalcaterraDepartment of Pediatrics, Buzzi Children's Hospital, University of Milan, 20154 Milan, Italy.
Gloria PelizzoDepartment of Pediatric Surgery, Buzzi Children's Hospital, 20154 Milan, Italy.
University of Milan · ITOspedale dei Bambini Vittore Buzzi · ITAzienda di Rilievo Nazionale ed Alta Specializzazione · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn children, laparoscopic cholecystectomy (LC) is now considered the gold standard for gallbladder (GB) removal. In the past, hemolytic disorders associated with cholelithiasis represented the most frequent conditions requiring LC; this is being overtaken by cholelithiasis and biliary conditions in overweight or ex-premature children.

aimsThis study aims to describe current indications and timing for LC in pediatric patients.

methodsRetrospective study. Data on previous medical therapy, ultrasound, pre- and intraoperative aspects, and histology were collected for patients treated in 2020-2023.

resultsIn total, 45 patients were enrolled: 15 who underwent urgent surgery and 30 electives. Groups differed in terms of obesity rate, symptoms, ultrasound features, and intraoperative status. The most relevant risk factors for surgical complexity were age and pubertal stage, elevated cholestasis indexes, and gallbladder wall thickness > 3 mm at ultrasound. GB wall thickening ≥3 mm, US Murphy sign, fluid collections, and gallbladder distention on ultrasound correlated with high surgical scores.

conclusionsIndications for laparoscopic cholecystectomy in children seem to evolve caused by changing characteristics of the pediatric population. Patients with overweight/obesity may develop more complex GB diseases. Asymptomatic patients should be considered for surgery after observation, considering age and/or pubertal maturation when other risk factors are absent.

Indexed as

childrencholecystectomycholelithiasislaparoscopysurgical timing

Identifiers

PMID38002862
PMCPMC10670818
OpenAlexW4388078361

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.