Evidence map›Paper›PMID 38002806›Full record

ReviewJournal of clinical medicine2023

Treatment Approaches to Molar Incisor Hypomineralization: A Systematic Review.

Angelo Michele Inchingolo, Alessio Danilo Inchingolo, Fabio Viapiano, Anna Maria Ciocia, Irene Ferrara, Anna Netti, Gianna Dipalma, Andrea Palermo, Francesco Inchingolo

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06922552 (Clinical Performance of Giomer Preceded by Etching Versus Resin-Based Sealants Applied on Permanent Molars Affected by Molar-Incisor Hypo-mineralization), which is not on this map. Cited by 33 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 6 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06922552 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Clinical Performance of Giomer Preceded by Etching Versus Resin-Based Sealants Applied on Permanent Molars Affected by Molar-Incisor Hypo-mineralization: A Randomized Clinical Trial

TypeinterventionalSponsorCairo UniversityRan2025 to 2026Enrolled56ConditionsMolar Incisor HypomineralizationArmsGiomer pit and fissure sealant with etching applied on Permanent Molars Affected by MIH, Resin based sealant applied on Permanent Molars Affected by MIH
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 6 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Impact of exposure to environmental chemicals on the occurrence of molar incisor hypomineralisation and developmental enamel defects in children: a systematic review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
    Pooled it
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  3. Effective anaesthesia when treating teeth affected by molar incisor hypomineralisation (MIH): a systematic review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025
    Pooled it
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  10. Esthetic Rehabilitation of Anterior Teeth With Diastemas and MIH-Related Enamel Opacities.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026
    Article
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  14. Materials (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Angelo Michele InchingoloDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-0104-6337
Alessio Danilo InchingoloDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-6366-1039
Fabio ViapianoDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0001-9568-9346
Anna Maria CiociaDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0001-7096-8189
Irene FerraraDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-4883-6232
Anna NettiDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-2215-0881
Gianna DipalmaDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-5947-8987
Andrea PalermoCollege of Medicine and Dentistry, Birmingham B4 6BN, UK.ORCID 0000-0002-3288-490X
Francesco InchingoloDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-3797-5883
University of Bari Aldo Moro · ITUniversity College Birmingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis systematic review aimed to comprehensively evaluate the available literature on treating molar incisor hypomineralization (MIH) or enamel hypomineralization published between 2013 and 2023, focusing on identifying relevant studies and their characteristics. MATERIALS AND

methodsThe search process encompassed reputable academic databases, including PubMed, Scopus, Cochrane Library, and Web of Science, using a precise keyword strategy ("((molar incisor hypomineralization) OR (enamel hypomineralization)) AND (treatment)"). A total of 637 articles were initially retrieved, followed by a strict selection process adhering to PRISMA guidelines. The inclusion criteria encompassed Randomized Control Trials (RCTs), case series with more than five clinical cases (CSs), studies involving human participants, availability as free full-text or accessible with university credentials, and English-language publications. Exclusion criteria included systematic or literature reviews, editorials, single-case reports, studies conducted in vitro, those involving animals, paid articles, and non-English-language publications.

resultsThe search yielded 864 articles, of which 23 met the stringent inclusion criteria after a meticulous selection process. These studies will serve as the basis for a comprehensive analysis of MIH treatment approaches. The systematic review ensures the quality and relevance of the chosen studies for a detailed assessment of MIH treatment strategies.

conclusionsThis systematic review will provide valuable insights into the characteristics of selected studies, patient profiles, and available treatment options for molar incisor hypomineralization, contributing to a better understanding of this dental condition's management.

Indexed as

caseinechildrenenamel defectenamel hypomineralizationfluoridemolar incisor hypomineralizationpediatric dentistrypreventive therapiesrestorative therapiessealanttherapytreatment

Identifiers

PMID38002806
PMCPMC10671994
OpenAlexW4388834730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.