Evidence map›Paper›PMID 38002739›Full record

ArticleJournal of clinical medicine2023

Atrial Strain Assessment for the Early Detection of Cancer Therapy-Related Cardiac Dysfunction in Breast Cancer Women (The STRANO STUDY: Atrial Strain in Cardio-Oncology).

Daniela Di Lisi, Antonella Moreo, Grazia Casavecchia, Christian Cadeddu Dessalvi, Corinna Bergamini, Concetta Zito, Cristina Madaudo, Rosalinda Madonna, Matteo Cameli, Giuseppina Novo

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  13. Left Atrial Strain-Current Review of Clinical Applications.Diagnostics (Basel, Switzerland) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

Daniela Di LisiDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (ProMISE), University of Palermo, Piazza delle Cliniche, 2, 90127 Palermo, Italy.ORCID 0000-0003-4510-6805
Antonella MoreoCardiology IV, "A. De Gasperis" Department, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy.ORCID 0000-0003-3150-3885
Grazia CasavecchiaCardiology Unit, Department of Medical and Surgical Sciences, University Hospital of Foggia, University of Foggia, 71122 Foggia, Italy.
Christian Cadeddu DessalviDepartment of Medical Sciences and Public Health, University of Cagliari, 09042 Cagliari, Italy.ORCID 0000-0002-2823-1797
Corinna BergaminiDepartment of Medicine, Division of Cardiology, University of Verona, 37129 Verona, Italy.
Concetta ZitoDepartment of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy.ORCID 0000-0002-6908-4316
Cristina MadaudoDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (ProMISE), University of Palermo, Piazza delle Cliniche, 2, 90127 Palermo, Italy.ORCID 0000-0002-9151-4335
Rosalinda MadonnaDepartment of Pathology, Cardiology Division, University of Pisa, 56124 Pisa, Italy.
Matteo CameliDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, 53100 Siena, Italy.ORCID 0000-0003-3872-8964
Giuseppina NovoDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (ProMISE), University of Palermo, Piazza delle Cliniche, 2, 90127 Palermo, Italy.
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITUniversity of Cagliari · ITUniversity of Foggia · ITUniversity of Messina · ITUniversity of Pisa · ITUniversity of Siena · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Left ventricular global longitudinal strain (GLS) has an important role in the diagnosis of cancer therapy-related cardiac dysfunction (CTRCD). Little is known about the role of atrial function in diagnosing CTRCD. The aim of our study was to assess the impact of anti-cancer drugs on atrial function measured by speckle-tracking echocardiography in breast cancer women. A prospective multicenter study was conducted enrolling 169 breast cancer women treated with anthracyclines. A cardiological evaluation including an electrocardiogram and echocardiogram with an analysis of GLS, left atrial (LA) strain, and LA stiffness (LASi) was performed at baseline (T0), 3 (T1), and 6 months (T2) after starting chemotherapy. The patients were divided into two groups: patients with asymptomatic mild cardiotoxicity at T1 (with a relative reduction in GLS > 15%; Group 1) and those without (Group 2). We did not find a significant change in left ventricular ejection fraction (LVEF) at T1 and T2; we found a significant change in GLS (

Indexed as

cardio-oncologycardiotoxicitychemotherapyCTRCDGLSleft atrial strain

Identifiers

PMID38002739
PMCPMC10672006
OpenAlexW4388733519

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.