ArticleJournal of clinical medicine2023
Pain Management, Functional Recovery, and Stress Response Expressed by NLR and PLR after the iPACK Block Combined with Adductor Canal Block for Total Knee Arthroplasty-A Prospective, Randomised, Double-Blinded Clinical Trial.
Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07367009 (The Effect of the Combination of Adductor Canal Block and Anterior Femoral Cutaneous Nerve Block on Postoperative Inflammatory Biomarkers in Total Knee Arthroplasty), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of the Combination of Adductor Canal Block and Anterior Femoral Cutaneous Nerve Block on Postoperative Inflammatory Biomarkers in Total Knee Arthroplasty
Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Association between pericapsular nerve group (PENG) block and postoperative inflammatory indices and analgesic outcomes in total hip arthroplasty: a randomized controlled trial.BMC anesthesiology · 2026Trial
- Effect of pericapsular nerve group block on postoperative cognitive function in older patients undergoing total hip arthroplasty.Die Anaesthesiologie · 2026Trial
- Combined iPACK and adductor canal block versus two-level erector spinae plane block in elderly patients undergoing total knee arthroplasty: a randomized, triple-blinded clinical trial.Archives of orthopaedic and trauma surgery · 2026Trial
- Effect of ultrasound-guided genicular nerve neurolysis versus sham procedure on pain in patients with knee osteoarthritis: a randomized clinical trial.Pain medicine (Malden, Mass.) · 2026Trial
- Dexamethasone as a perineural adjuvant to a ropivacaine popliteal sciatic nerve block for pediatric foot surgery: a randomized, double-blind, placebo-controlled trial.Regional anesthesia and pain medicine · 2025Trial
- Erector spinae plane block (ESPB) vs. pericapsular nerve group (PENG) block in total hip arthroplasty in elderly patients: a randomized, double-blinded, controlled trial.Anaesthesiology intensive therapy · 2025Trial
- Enhanced Postoperative Pain Management and Mobility Following Arthroscopic Knee Surgery: A Comparative Study of Adductor Canal Block with and without IPACK Block.Medical science monitor : international medical journal of experimental and clinical research · 2024Trial
- Motor-Sparing Regional Analgesia in Frail and Sarcopenic Older Adults Undergoing Total Knee Arthroplasty: From Anatomy to Clinical Decision-Making-A Narrative Review.Journal of clinical medicine · 2026Review
- Inflammatory Biomarkers Following Orthopedic Surgery: Current Evidence, Clinical Applications, and Future Perspectives-A Narrative Review.Journal of clinical medicine · 2026Review
- Dexamethasone vs. Dexmedetomidine as Adjuvants to Erector Spinae Plane Block in Total Knee Arthroplasty: A Randomized Double-Blind Controlled Trial.Journal of clinical medicine · 2026Article
- A novel technique of intraoperative infiltration between posterior capsule and popliteal artery can reduce opioid consumption and blood loss in total knee arthroplasty surgery: an age- and gender-matched study.Journal of orthopaedic surgery and research · 2025Article
- The Influence of Anesthesia on Neuromonitoring During Scoliosis Surgery: A Systematic Review.NeuroSci · 2024Review
- The Influence of Regional Anesthesia on the Systemic Stress Response.Reports (MDPI) · 2024Review
- Negative and Positive Predictors of Anastomotic Leakage in Colorectal Cancer Patients-The Case of Neutrophil-to-Lymphocyte Ratio.Diagnostics (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study aimed to investigate pain management, functional recovery, and stress response expressed by the neutrophile-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) after the popliteal artery and posterior knee capsule infiltration (iPACK) block combined with adductor canal block (ACB) in total knee arthroplasty (TKA). PATIENTS AND
methodsThis was a prospective, double-blinded, randomised, controlled trial in a tertiary referral hospital. Three hundred and sixty-six patients were randomly allocated into the sham block group and iPACK combined with the ACB group. The primary outcome was postoperative pain scores. The secondary outcomes were opioid consumption, functional recovery expressed by a range of motion, and quadriceps strength. Also, the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were calculated.
resultsThere were significant differences between the sham block and iPACK + ACB group in pain scores
conclusionAfter total knee arthroplasty, the iPACK combined with ACB block group improved pain management, functional recovery, and stress response. Therefore, we strongly recommend this technique as a part of a multimodal analgesia protocol in knee surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.