Evidence map›Paper›PMID 38002666›Full record

ArticleJournal of clinical medicine2023

Anthracycline's Effects on Heart Rate Variability in Children with Acute Lymphoblastic Leukemia: Early Toxicity Signs-Pilot Study.

Diana R Lazar, Simona Cainap, Dana Maniu, Cristina Blag, Madalina Bota, Florin-Leontin Lazar, Alexandru Achim, Marius C Colceriu, Mihnea Zdrenghea

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Diana R LazarDepartment No. 11, Oncology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.ORCID 0000-0001-7000-9949
Simona CainapDepartment of Pediatric Cardiology, Emergency Hospital for Children, 400394 Cluj-Napoca, Romania.
Dana ManiuBiomolecular Physics Department, Faculty of Physics, "Babes-Bolyai" University, 400347 Cluj-Napoca, Romania.ORCID 0000-0002-3759-6544
Cristina BlagDepartment of Mother and Child, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.ORCID 0000-0003-4111-1295
Madalina BotaDepartment of Mother and Child, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Florin-Leontin LazarDepartment No. 5, Internal Medicine, Medical Clinic Number 1, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Alexandru AchimDepartment of Cardiology, "Niculae Stancioiu" Heart Institute, Motilor 19-21, 400001 Cluj-Napoca, Romania.ORCID 0000-0002-5540-3478
Marius C ColceriuDepartment of Functional Biosciences, Discipline of Physiology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.ORCID 0009-0001-8023-2631
Mihnea ZdrengheaDepartment No. 11, Oncology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.ORCID 0000-0002-9461-987X
Iuliu Hațieganu University of Medicine and Pharmacy · ROBabeș-Bolyai University · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anthracycline treatments are known to cause cardiotoxic long-term side effects in cancer survivors. Recently, a decrease in heart rate variability (HRV) has been identified in these patients, signaling autonomic dysfunction and altered cardiac fitness. This study aimed at evaluating changes in HRV in children treated with anthracyclines. A total of 35 pediatric patients with acute lymphoblastic leukemia were evaluated by means of a 24 h Holter ECG, at baseline and after reaching half the total cumulative dose of doxorubicin equivalent (120 mg/m

Indexed as

cardiotoxicitychildhood cancerearly cardiac dysfunctionheart rate variability

Identifiers

PMID38002666
PMCPMC10672281
OpenAlexW4388637954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.