Evidence map›Paper›PMID 38002558›Full record

ArticleBrain sciences2023

Abnormal Topological Organization of White Matter Structural Networks in Normal Tension Glaucoma Revealed via Diffusion Tensor Tractography.

Yin Wang, Linying Guo, Rong Wang, Yuzhe Wang, Fei Duan, Yang Zhan, Jingfeng Cheng, Xinghuai Sun, Zuohua Tang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Yin WangDepartment of Radiology, Eye & ENT Hospital of Fudan University, Fudan University, Shanghai 200031, China.
Linying GuoDepartment of Radiology, Eye & ENT Hospital of Fudan University, Fudan University, Shanghai 200031, China.
Rong WangDepartment of Radiology, Huashan Hospital of Fudan University, Fudan University, Shanghai 200040, China.
Yuzhe WangDepartment of Radiology, Zhongshan Hospital of Fudan University, Fudan University, Shanghai 200032, China.
Fei DuanDepartment of Radiology, Eye & ENT Hospital of Fudan University, Fudan University, Shanghai 200031, China.
Yang ZhanDepartment of Radiology, Zhongshan Hospital of Fudan University, Fudan University, Shanghai 200032, China.
Jingfeng ChengDepartment of Radiology, Eye & ENT Hospital of Fudan University, Fudan University, Shanghai 200031, China.
Xinghuai SunDepartment of Ophthalmology & Visual Science, Eye & ENT Hospital of Fudan University, Fudan University, Shanghai 200031, China.
Zuohua TangDepartment of Radiology, Eye & ENT Hospital of Fudan University, Fudan University, Shanghai 200031, China.
Eye & ENT Hospital of Fudan University · CNFudan University · CNHuashan Hospital · CNZhongshan Hospital · CN

Funding

National Natural Science Foundation of China 81871341National Natural Science Foundation of China 82271945
6 · The paper itself

Abstract

backgroundNormal tension glaucoma (NTG) is considered a neurodegenerative disease with glaucomatous damage extending to diffuse brain areas. Therefore, this study aims to explore the abnormalities in the NTG structural network to help in the early diagnosis and course evaluation of NTG.

methodsThe structural networks of 46 NTG patients and 19 age- and sex-matched healthy controls were constructed using diffusion tensor imaging, followed by graph theory analysis and correlation analysis of small-world properties with glaucoma clinical indicators. In addition, the network-based statistical analysis (NBS) method was used to compare structural network connectivity differences between NTG patients and healthy controls.

resultsStructural brain networks in both NTG and NC groups exhibited small-world properties. However, the small-world index in the severe NTG group was reduced and correlated with a mean deviation of the visual field (MDVF) and retinal nerve fiber layer (RNFL) thickness. When compared to healthy controls, degree centrality and nodal efficiency in visual brain areas were significantly decreased, and betweenness centrality and nodal local efficiency in both visual and nonvisual brain areas were also significantly altered in NTG patients (all

conclusionsNTG exhibited altered global properties and local properties of visual and cognitive-emotional brain areas, with enhanced structural connections within the occipitotemporal area. Moreover, the disrupted small-world properties of white matter might be imaging biomarkers for assessing NTG progression.

Indexed as

diffusion tensor imagingnormal tension glaucomasmall-world propertiesstructural networks

Identifiers

PMID38002558
PMCPMC10669977
OpenAlexW4388759986

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.