Evidence map›Paper›PMID 38002522›Full record

ArticleBrain sciences2023

Mechanisms of Sustained Increases in

Maximilian Petzi, Selena Singh, Thomas Trappenberg, Abraham Nunes

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Maximilian PetziFaculty of Computer Science, Dalhousie University, Halifax, NS B3H 4R2, Canada.
Selena SinghDepartment of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, ON L8S 4L6, Canada.
Thomas TrappenbergFaculty of Computer Science, Dalhousie University, Halifax, NS B3H 4R2, Canada.ORCID 0000-0002-6144-8963
Abraham NunesFaculty of Computer Science, Dalhousie University, Halifax, NS B3H 4R2, Canada.ORCID 0000-0002-4955-9150
Dalhousie University · CAMcMaster University · CA

Funding

Nova Scotia Health Research Foundation RNS-NHIG-2021-1931
6 · The paper itself

Abstract

Subanaesthetic doses of ketamine increase γ oscillation power in neural activity measured using electroencephalography (EEG), and this effect lasts several hours after ketamine administration. The mechanisms underlying this effect are unknown. Using a computational model of the hippocampal cornu ammonis 3 (CA3) network, which is known to reproduce ketamine's acute effects on γ power, we simulated the plasticity of glutamatergic synapses in pyramidal cells to test which of the following hypotheses would best explain this sustained γ power:

Indexed as

CA3computational modeldepressionhippocampusketamineneuron

Identifiers

PMID38002522
PMCPMC10670117
OpenAlexW4388452739

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.