Evidence map›Paper›PMID 38002515›Full record

ArticleBrain sciences2023

Poor Oral Health Linked with Higher Risk of Alzheimer's Disease.

Mihir S Kulkarni, Brandi C Miller, Manan Mahani, Rahul Mhaskar, Athanasios Tsalatsanis, Shalini Jain, Hariom Yadav

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mihir S KulkarniUSF Center for Microbiome Research, Microbiomes Institute, Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL 33612, USA.
Brandi C MillerUSF Center for Microbiome Research, Microbiomes Institute, Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0002-6986-999X
Manan MahaniUSF Center for Microbiome Research, Microbiomes Institute, Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL 33612, USA.
Rahul MhaskarDepartment of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Athanasios TsalatsanisResearch Methodology and Biostatistics Core, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Shalini JainUSF Center for Microbiome Research, Microbiomes Institute, Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL 33612, USA.
Hariom YadavUSF Center for Microbiome Research, Microbiomes Institute, Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0003-4504-1597
University of South Florida · US

Funding

Repurposing of Metormin for Older Patients with HFpEFU01AG076928 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W, YADAV, HARIOM · 2022 to 2024
$2.3M
Gut microbiota-based biomarkers of Alzheimer's disease and its modulation by a ketogenic dietR56AG064075 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI YADAV, HARIOM · 2020 to 2021
$1.2M
Microbial therapy improves gut permeability to reduce cognitive decline and Alzheimer’s diseaseRF1AG071762 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI YADAV, HARIOM · 2021 to 2021
$1.1M
The role of gut microbiota in the efficacy of ketogenic diet to ameliorate Alzheimer's diseaseR21AG072379 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI YADAV, HARIOM · 2021 to 2021
$429k
Identification of bacterial strains for development of an oral probiotic aimed at increasing nitric oxide bioavailabilityR21DE032197 · NIDCR · WAKE FOREST UNIVERSITY · PI KIM-SHAPIRO, DANIEL B, YADAV, HARIOM · 2023 to 2024
$422k
Saliva based protein markers for predicting the risk of cognitive decline and dementia in older adults.R21AG082164 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI JAIN, SHALINI · 2023 to 2024
$412k
Metformin and Alzheimer's disease: Underlying Mechanisms that Ameliorate ProgressionR56AG069676 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI YADAV, HARIOM · 2020 to 2020
$388k
NIA NIH HHS R21 AG072379NIA NIH HHS R21 AG082164NIA NIH HHS R56 AG064075NIA NIH HHS R56 AG069676NIA NIH HHS RF1 AG071762NIA NIH HHS U01 AG076928NIDCR NIH HHS R21 DE032197
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a multifactorial neurodegenerative disease characterized by cognitive and behavioral changes in older adults. Emerging evidence suggests poor oral health is associated with AD, but there is a lack of large-scale clinical studies demonstrating this link. Herein, we used the TriNetX database to generate clinical cohorts and assess the risk of AD and survival among >30 million de-identified subjects with normal oral health (

Indexed as

Alzheimer’s diseasecognitiondementiaoral healthoral microbiome

Identifiers

PMID38002515
PMCPMC10669972
OpenAlexW4388459725

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.