Evidence map›Paper›PMID 38002476›Full record

ArticleBrain sciences2023

Neoadjuvant Chemotherapy with Laser Interstitial Thermal Therapy in Central Nervous System Neuroblastoma: Illustrative Case and Literature Review.

Jason E Chung, Omar Iqbal, Chandra Krishnan, Virginia Harrod, Elizabeth Tyler-Kabara, Rongze O Lu, Winson S Ho

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Editorial forBrain sciences · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jason E ChungDepartment of Neurological Surgery, University of California, San Francisco, CA 94110, USA.
Omar IqbalDepartment of Neurosurgery, Dell Medical School, University of Texas at Austin, Austin, TX 78712, USA.
Chandra KrishnanDepartment of Diagnostic Medicine, Dell Medical School, University of Texas at Austin, Austin, TX 78712, USA.
Virginia HarrodDepartment of Pediatrics, Dell Medical School, University of Texas at Austin, Austin, TX 78723, USA.
Elizabeth Tyler-KabaraDepartment of Neurosurgery, Dell Medical School, University of Texas at Austin, Austin, TX 78712, USA.
Rongze O LuDepartment of Neurological Surgery, University of California, San Francisco, CA 94110, USA.
Winson S HoDepartment of Neurological Surgery, University of California, San Francisco, CA 94110, USA.ORCID 0000-0001-5943-1436
The University of Texas at Austin · USUniversity of California, San Francisco · US

Funding

Regulation of Macrophage- and Microglia-mediated STING Signaling in GlioblastomaR01NS126501 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Rongze Olivia Lu · 2022 to 2026
$1.9M
Regulation of Tumor Immunogenicity in GlioblastomaR01NS131545 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Sze Chun Winson Ho · 2023 to 2026
$1.8M
NINDS NIH HHS R01 NS126501NINDS NIH HHS R01 NS131545NINDS NIH HHS R01NS131545
6 · The paper itself

Abstract

Primitive neuroectodermal tumors of the central nervous system, or CNS neuroblastoma, are rare neoplasms in children. Recently, methylation profiling enabled the discovery of four distinct entities of these tumors. The current treatment paradigm involves surgical resection followed by chemotherapy and radiation. However, upfront surgical resection carries high surgical morbidity in this patient population due to their young age, tumor vascularity, and often deep location in the brain. We report a case of CNS neuroblastoma that can be successfully treated with neoadjuvant chemotherapy followed by minimally invasive laser interstitial thermal therapy and radiation. The patient has complete treatment with no evidence of recurrence at one year follow-up. This case illustrates a potential paradigm shift in the treatment of these rare tumors can be treated using minimally invasive surgical approach to achieve a favorable outcome.

Indexed as

CNS neuroblastomalaser interstitial thermal therapyLITT

Identifiers

PMID38002476
PMCPMC10669297
OpenAlexW4388013541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.