Evidence map›Paper›PMID 38002473›Full record

ArticleBrain sciences2023

CSF, Blood, and MRI Biomarkers in Skogholt's Disease-A Rare Neurodegenerative Disease in a Norwegian Kindred.

Klaus Thanke Aspli, Jan O Aaseth, Trygve Holmøy, Kaj Blennow, Henrik Zetterberg, Bjørn-Eivind Kirsebom, Tormod Fladby, Per Selnes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 6 countries.

Klaus Thanke AspliDepartment of Neurology, Innlandet Hospital Trust, 2381 Lillehammer, Norway.
Jan O AasethResearch Department, Innlandet Hospital Trust, 2381 Brumunddal, Norway.ORCID 0000-0002-7518-5703
Trygve HolmøyInstitute of Clinical Medicine, University of Oslo, 0316 Oslo, Norway.
Kaj BlennowInstitute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, 43153 Mölndal, Sweden.
Henrik ZetterbergInstitute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, 43153 Mölndal, Sweden.
Bjørn-Eivind KirsebomInstitute of Clinical Medicine, University of Oslo, 0316 Oslo, Norway.
Tormod FladbyInstitute of Clinical Medicine, University of Oslo, 0316 Oslo, Norway.
Per SelnesInstitute of Clinical Medicine, University of Oslo, 0316 Oslo, Norway.ORCID 0000-0001-5131-9757
University of Oslo · NOInnlandet Hospital Trust · NOUniversity Hospital of North Norway · NOUniversity of Science and Technology of China · CNUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skogholt's disease is a rare neurological disorder that is only observed in a small Norwegian kindred. It typically manifests in adulthood with uncharacteristic neurological symptoms from both the peripheral and central nervous systems. The etiology of the observed cerebral white matter lesions and peripheral myelin pathology is unclear. Increased cerebrospinal fluid (CSF) concentrations of protein have been confirmed, and recently, very high concentrations of CSF total and phosphorylated tau have been detected in Skogholt patients. The symptoms and observed biomarker changes in Skogholt's disease are largely nonspecific, and further studies are necessary to elucidate the disease mechanisms. Here, we report the results of neurochemical analyses of plasma and CSF, as well as results from the morphometric segmentation of cerebral magnetic resonance imaging. We analyzed the biomarkers Aβ

Indexed as

amyloid betablood–brain barrierGFAPMRINFLPDGFRβSkogholt’s diseasetau proteinβ-trace protein

Identifiers

PMID38002473
PMCPMC10669496
OpenAlexW4387958735

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.