Evidence map›Paper›PMID 38002462›Full record

ArticleBrain sciences2023

The Mediation Role of Sleep Disturbances between Vitamin D and Depressive Symptoms: A Cross-Sectional Study.

Lihua Yao, Mianmian Chen, Nan Zhang, Simeng Ma, Xinhui Xie, Shuxian Xu, Zhaowen Nie, Wei Wang, Enqi Zhou, Shunsheng Xu and 4 more

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Lihua YaoDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Mianmian ChenDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Nan ZhangDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Simeng MaDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Xinhui XieDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, China.ORCID 0000-0002-3603-3854
Shuxian XuDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Zhaowen NieDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Wei WangDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Enqi ZhouDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Shunsheng XuDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Shenhong WengDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Hexiang ChenDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Dan XiangDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Zhongchun LiuDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, China.ORCID 0000-0001-5410-0312
Wuhan University · CN

Funding

National Key R&D Program of China 2018YFC1314600National Natural Science Foundation of China U21A20364
6 · The paper itself

Abstract

Depression and sleep disturbances are highly prevalent health problems that have been suggested to be associated with vitamin D deficiency. This study investigated whether sleep disturbances affect the association between vitamin D and depressive symptoms. A total of 425 patients with depression were included in this study. Spearman correlation coefficients were chosen to assess the relation between vitamin D concentrations and depressive symptomatology (according to the PHQ-9 and HAMD-17 scores). The GLM Mediation Model in the Medmod module for data analysis in Jamovi 2.2.5 was used to analyze the mediation models for sleep disturbances. Vitamin D concentrations were significantly correlated with PHQ-9 and HAMD-17 scale scores. In addition, item 3 was suggested to have a mediating effect between vitamin D and depressive symptoms in the mediating model of PHQ-9, and item 4 was suggested to have a mediating effect between vitamin D and depressive symptoms in the mediating model of HAMD-17. Sleep disturbances (especially difficulty falling asleep) are mediators between vitamin D and depressive symptoms, suggesting that increasing vitamin D levels at the right time to regulate sleep disturbances may improve depression symptoms, yet further research is necessary.

Indexed as

depressionHAMD-17mediationPHQ-9sleepvitamin D

Identifiers

PMID38002462
PMCPMC10669134
OpenAlexW4387903954

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.