Evidence map›Paper›PMID 38002399›Full record

ReviewBioengineering (Basel, Switzerland)2023

Molecular and Biological Aspects of Orthodontic Tooth Movement: Possibilities for Bioengineering Intervention: A Narrative Review.

Ioannis A Tsolakis, Isidora Christopoulou, Symeon Sitaras, Ioannis Lyros, Aliki Rontogianni, Maria Dalampira, Apostolos I Tsolakis

Abstract readReview
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  5. Epigenetic Connections in Malocclusion.International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ioannis A TsolakisDepartment of Orthodontics, School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0002-5435-4889
Isidora ChristopoulouDepartment of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Symeon SitarasPrivate Practice, 54124 Thessaloniki, Greece.
Ioannis LyrosDepartment of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0002-5897-6116
Aliki RontogianniDepartment of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0003-0218-2963
Maria DalampiraPrivate Practice, 54124 Thessaloniki, Greece.ORCID 0009-0003-1976-7949
Apostolos I TsolakisDepartment of Orthodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0003-3019-5438

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe current review's goal is to examine, with a critical eye, the effect of various biomedical parameters on orthodontic tooth movement in an attempt to provide the reader with related mechanisms of this issue focusing on certain key points.

methodsThis critical review was conducted using the following keywords in the search strategy: "biomedical molecules", "biomarkers", "orthodontics", "orthodontic tooth movement", "acceleration", "gene therapy", and "stem cells". Cochrane Library, Medline (PubMed), and Scopus were the databases that were used for the electronic search. Studies published until June 2023 were considered.

resultsThe use of biomedical approaches in orthodontic tooth movement has been investigated via different procedures and applications. Surgical approaches, biomarkers affecting orthodontic tooth movement, different biological events and mechanisms, RANK, RANK-L, OPG molecular triad, and vibration methods are the basic parameters of biomedical interventions that are examined in the present review.

conclusionsThe biomedical approach seems to offer a variety of applications to control orthodontic tooth movement. The scarcity of human studies, as well as the high cost and complexity of these methods, currently limit the available accurate data concerning this issue.

Indexed as

biomarkersbiomedical moleculesorthodontic tooth movementRANKRANK-L OPGvibration methods

Identifiers

PMID38002399
PMCPMC10669634

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.