Evidence map›Paper›PMID 38002358›Full record

ArticleBiomolecules2023

Visible Light-Induced Templated Metathesis of Peptide-Nucleic Acid Conjugates with a Diselenide Bridge.

Mateusz Waliczek, Wiktoria Gancarz, Paulina Pochwała, Özge Pehlivan, Piotr Stefanowicz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mateusz WaliczekFaculty of Chemistry, University of Wrocław, Joliot-Curie 14, 50-383 Wrocław, Poland.ORCID 0000-0003-3238-2747
Wiktoria GancarzFaculty of Chemistry, University of Wrocław, Joliot-Curie 14, 50-383 Wrocław, Poland.ORCID 0009-0009-3989-069X
Paulina PochwałaFaculty of Chemistry, University of Wrocław, Joliot-Curie 14, 50-383 Wrocław, Poland.
Özge PehlivanFaculty of Chemistry, University of Wrocław, Joliot-Curie 14, 50-383 Wrocław, Poland.ORCID 0000-0002-0465-0161
Piotr StefanowiczFaculty of Chemistry, University of Wrocław, Joliot-Curie 14, 50-383 Wrocław, Poland.ORCID 0000-0001-9581-2359
University of Wrocław · PL

Funding

National Science Center DEC-2022/06/X/ST4/00305
6 · The paper itself

Abstract

The use of template molecules as chemical scaffolds that significantly influence the course of the reaction has recently been intensively studied. Peptide nucleic acids (PNA) are molecules that mimic natural nucleic acids. They are a promising matrix in such reactions because they possess high affinity and specificity in their interactions. The manner of PNA interaction is predictable based on sequence complementarity. Recently, we report the visible light-induced metathesis reaction in peptides containing a diselenide bond. Herein, we present an efficient and straightforward method of the visible light-driven diselenide-based metathesis of peptide-nucleic acid conjugates. Compared to a similar photochemical transformation in peptides, a significant increase in the metathesis efficiency was obtained due to the template effect.

Indexed as

Nucleic AcidsPeptide Nucleic AcidsLightPeptidesNucleic AcidsPeptide Nucleic AcidsPeptidesmetathesispeptide nucleic acidseleniumtemplated synthesis

Identifiers

PMID38002358
PMCPMC10669671
OpenAlexW4388824200

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.