ArticleBiomolecules2023
Synthesis and Biological Evaluation of Benzo [4,5]- and Naphtho[2',1':4,5]imidazo[1,2-c]pyrimidinone Derivatives.
Polina Kamzeeva, Nikolai Dagaev, Sofia Lizunova, Yuri Khodarovich, Anna Sogomonyan, Anastasia Kolchanova, Vadim Pokrovsky, Vera Alferova, Alexey Chistov, Artur Eshtukov-Shcheglov and 5 more
Open access · goldAbstract read
In one paragraphArticle in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
What it found
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
15 authors at 8 institutions in 2 countries.
Polina KamzeevaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Nikolai DagaevDepartment of Chemistry and Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991 Moscow, Russia.
Sofia LizunovaLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.
Yuri KhodarovichShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.ORCID 0000-0002-0162-4857 Anna SogomonyanShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.ORCID 0000-0002-4139-6625 Anastasia KolchanovaDepartment of Chemistry and Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991 Moscow, Russia.
Vera AlferovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.ORCID 0000-0002-8961-5890 Alexey ChistovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Artur Eshtukov-ShcheglovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Elizaveta Eshtukova-ShcheglovaLomonosov Institute of Fine Chemical Technology, MIREA-Russian Technological University, 119571 Moscow, Russia.ORCID 0000-0002-3729-4466 Evgeny BelyaevFrumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 119071 Moscow, Russia.
Dmitry SkvortsovDepartment of Chemistry and Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991 Moscow, Russia.
Anna VarizhukLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.
Andrey AralovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.ORCID 0000-0003-3268-2352 Institute of Bioorganic Chemistry · RULomonosov Moscow State University · RUPeoples' Friendship University of Russia · RUFederal Medical-Biological Agency · RUFrumkin Institute of Physical Chemistry and Electrochemistry · RUMIREA - Russian Technological University · RUMoscow Institute of Physics and Technology · RUUniversity of Pavia · IT
Funding
Russian Science Foundation 22-14-00099State Program of the Ministry of Science and Higher Education of the Russian Federation no. 075-01551-23-00; FSSF-2023-0006
6 · The paper itselfAbstract
Azacarbazoles have attracted significant interest due to their valuable properties, such as anti-pathogenic and antitumor activity. In this study, a series of structurally related tricyclic benzo[4,5]- and tertacyclic naphtho[2',1':4,5]imidazo[1,2-c]pyrimidinone derivatives with one or two positively charged tethers were synthesized and evaluated for anti-proliferative activity. Lead tetracyclic derivative
Indexed as
Antineoplastic AgentsLung NeoplasmsAnimalsApoptosisCell Line, TumorCell ProliferationG2 Phase Cell Cycle CheckpointsMiceMolecular StructureAntineoplastic Agentsanti-proliferative activityazacarbazolescytostatic agentimidazopyrimidinone
Identifiers
PMID38002351
PMCPMC10669118
OpenAlexW4388830421
What OpenQuestion holds
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LicenceCC BY
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