Evidence map›Paper›PMID 38002337›Full record

ArticleBiomolecules2023

Koray Ütkür, Sarina Schmidt, Klaus Mayer, Roland Klassen, Ulrich Brinkmann, Raffael Schaffrath

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Bacterial exotoxins in medicine: potential value and perspectives.International journal of medical sciences · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Koray ÜtkürInstitut für Biologie, Fachgebiet Mikrobiologie, Universität Kassel, 34132 Kassel, Germany.
Sarina SchmidtInstitut für Biologie, Fachgebiet Mikrobiologie, Universität Kassel, 34132 Kassel, Germany.
Klaus MayerRoche Pharma Research and Early Development (pRED), Large Molecule Research, Roche Innovation Center Munich, 82377 Penzberg, Germany.
Roland KlassenInstitut für Biologie, Fachgebiet Mikrobiologie, Universität Kassel, 34132 Kassel, Germany.ORCID 0000-0002-0809-0050
Ulrich BrinkmannRoche Pharma Research and Early Development (pRED), Large Molecule Research, Roche Innovation Center Munich, 82377 Penzberg, Germany.ORCID 0000-0002-5558-0212
Raffael SchaffrathInstitut für Biologie, Fachgebiet Mikrobiologie, Universität Kassel, 34132 Kassel, Germany.ORCID 0000-0001-9484-5247
University of Kassel · DERoche Pharma AG (Germany) · DE

Funding

Deutsche Forschungsgemeinschaft Priority Program 1927 Iron-Sulfur for Life (SCHA750/21-1)Zentraler Forschungsfonds (ZFF, Universität Kassel, Germany) Diphthamide Pilotgrant (#2887)
6 · The paper itself

Abstract

In eukaryotes, the Dph1•Dph2 dimer is a non-canonical radical SAM enzyme. Using iron-sulfur (FeS) clusters, it cleaves the cosubstrate S-adenosyl-methionine (SAM) to form a 3-amino-3-carboxy-propyl (ACP) radical for the synthesis of diphthamide. The latter decorates a histidine residue on elongation factor 2 (EF2) conserved from archaea to yeast and humans and is important for accurate mRNA translation and protein synthesis. Guided by evidence from archaeal orthologues, we searched for a putative SAM-binding pocket in Dph1•Dph2 from

Indexed as

HistidineSaccharomyces cerevisiaeHumansMinor Histocompatibility AntigensMutationPeptide Elongation Factor 2S-AdenosylmethionineTumor Suppressor ProteinsdiphthamideDPH1 protein, humanHistidineMinor Histocompatibility AntigensPeptide Elongation Factor 2S-AdenosylmethionineTumor Suppressor ProteinsADP ribosylationdiphtheria toxinDph1•Dph2EF2 diphthamide modificationradical SAM enzymesSaccharomyces cerevisiaeSAM

Identifiers

PMID38002337
PMCPMC10669111
OpenAlexW4388731650

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.