Evidence map›Paper›PMID 38002313›Full record

ArticleBiomolecules2023

Probing the Proton-Gated ASIC Channels Using Tetraalkylammonium Ions.

Konstantin K Evlanenkov, Maxim V Nikolaev, Natalia N Potapieva, Konstantin V Bolshakov, Denis B Tikhonov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Konstantin K EvlanenkovSechenov Institute of Evolutionary Physiology and Biochemistry RAS, St. Petersburg 194223, Russia.
Maxim V NikolaevSechenov Institute of Evolutionary Physiology and Biochemistry RAS, St. Petersburg 194223, Russia.
Natalia N PotapievaSechenov Institute of Evolutionary Physiology and Biochemistry RAS, St. Petersburg 194223, Russia.
Konstantin V BolshakovSechenov Institute of Evolutionary Physiology and Biochemistry RAS, St. Petersburg 194223, Russia.
Denis B TikhonovSechenov Institute of Evolutionary Physiology and Biochemistry RAS, St. Petersburg 194223, Russia.ORCID 0000-0001-8523-4305
Institute of Evolutionary Physiology and Biochemistry · RU

Funding

Russian Science Foundation 21-14-00280
6 · The paper itself

Abstract

The action of tetraalkylammonium ions, from tetrametylammonium (TMA) to tetrapentylammonium (TPtA), on the recombinant and native acid-sensing ion channels (ASICs) was studied using the patch-clamp approach. The responses of ASIC1a, ASIC2a, and native heteromeric ASICs were inhibited by TPtA. The peak currents through ASIC3 were unaffected, whereas the steady-state currents were significantly potentiated. This effect was characterized by an EC

Indexed as

Acid Sensing Ion ChannelsProtonsHydrogen-Ion ConcentrationQuaternary Ammonium CompoundsAcid Sensing Ion ChannelsProtonsQuaternary Ammonium Compoundstetrapentylammoniumchannel blockgating modulationstructure–activity relationshiptetraalkylammonium ions

Identifiers

PMID38002313
PMCPMC10669046
OpenAlexW4388500137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.