Evidence map›Paper›PMID 38002309›Full record

ArticleBiomolecules2023

Controlling Trophoblast Cell Fusion in the Human Placenta-Transcriptional Regulation of Suppressyn, an Endogenous Inhibitor of Syncytin-1.

Jun Sugimoto, Danny J Schust, Makiko Sugimoto, Yoshihiro Jinno, Yoshiki Kudo

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Genetic Diversity in theBiomolecules · 2025
    Article
  10. Article
  11. Trophoblast Fusion in Hypertensive Disorders of Pregnancy and Preeclampsia.International journal of molecular sciences · 2025
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Jun SugimotoDepartment of Obstetrics and Gynecology, Graduate School of Medical Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
Danny J SchustDepartment of Obstetrics and Gynecology, Duke University, Durham, NC 27710, USA.
Makiko SugimotoDepartment of Obstetrics and Gynecology, Graduate School of Medical Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
Yoshihiro JinnoDepartment of Molecular Biology, University of the Ryukyus, Okinawa 903-0215, Japan.
Yoshiki KudoDepartment of Obstetrics and Gynecology, Graduate School of Medical Sciences, Hiroshima University, Hiroshima 734-8551, Japan.ORCID 0000-0001-6542-3408
Hiroshima University · JPDuke University · USUniversity of the Ryukyus · JP

Funding

Modeling Normal and Abnormal TrophoblastsR01HD094937 · NICHD · UNIVERSITY OF MISSOURI-COLUMBIA · PI R. MICHAEL ROBERTS, Laura Clamon SCHULZ · 2018 to 2026
$4.5M
NICHD NIH HHS R01 HD094937
6 · The paper itself

Abstract

Cell fusion in the placenta is tightly regulated. Suppressyn is a human placental endogenous retroviral protein that inhibits the profusogenic activities of another well-described endogenous retroviral protein, syncytin-1. In this study, we aimed to elucidate the mechanisms underlying suppressyn's placenta-specific expression. We identified the promoter region and a novel enhancer region for the gene encoding suppressyn,

Indexed as

Endogenous RetrovirusesTrophoblastsCell FusionFemaleGene Products, envHumansOxygenPlacentaPregnancyPregnancy ProteinsERVH48-1 protein, humanGene Products, envOxygenPregnancy Proteinssyncytincell fusionDNA methylationHERVhypoxia inducible factor (HIF)placentapromotersuppressynsyncytin

Identifiers

PMID38002309
PMCPMC10668956
OpenAlexW4388465351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.