Evidence map›Paper›PMID 38002271›Full record

ArticleBiomolecules2023

LC-MS/MS Quantitation of HILIC-Enriched

Mojgan Atashi, Cristian D Gutierrez Reyes, Vishal Sandilya, Waziha Purba, Parisa Ahmadi, Md Abdul Hakim, Firas Kobeissy, Giuseppe Plazzi, Monica Moresco, Bartolo Lanuzza and 2 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
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  9. Analytical and bioanalytical chemistry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Mojgan AtashiDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0009-0002-9518-3833
Cristian D Gutierrez ReyesDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0000-0001-5229-4723
Vishal SandilyaDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.
Waziha PurbaDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.
Parisa AhmadiDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0000-0003-0184-4224
Md Abdul HakimDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.
Firas KobeissyDepartment of biochemistry and molecular genetics, Faculty of Biochemistry and Molecular Genetics, American University of Beirut, Beirut 11072020, Lebanon.ORCID 0000-0002-5008-6944
Giuseppe PlazziIRCCS, Instituto delle Scienze Neurologiche di Bologna, 40124 Bologna, Italy.
Monica MorescoIRCCS, Instituto delle Scienze Neurologiche di Bologna, 40124 Bologna, Italy.
Bartolo LanuzzaSleep Research Center, Department of Neurology IC, Oasi Research Institute-IRCCS, 94018 Tronia, Italy.
Raffaele FerriSleep Research Center, Department of Neurology IC, Oasi Research Institute-IRCCS, 94018 Tronia, Italy.ORCID 0000-0001-6937-3065
Yehia MechrefDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0000-0002-6661-6073
Texas Tech University · USI.R.C.C.S. Oasi Maria SS · ITIstituto delle Scienze Neurologiche di Bologna · ITMorehouse School of Medicine · USUniversity of Modena and Reggio Emilia · IT

Funding

Sensitive and Quantitative MS-bases Glycomic Mapping PlatformR01GM112490 · NIGMS · TEXAS TECH UNIVERSITY · PI MECHREF, YEHIA · 2014 to 2024
$3.2M
Quantitative Characterization of Glycopeptide IsomersR01GM130091 · NIGMS · TEXAS TECH UNIVERSITY · PI Yehia Mechref · 2019 to 2026
$2.5M
NIGMS NIH HHS R01 GM112490NIGMS NIH HHS R01 GM130091
6 · The paper itself

Abstract

Glycoproteomic analysis is always challenging because of low abundance and complex site-specific heterogeneity. Glycoproteins are involved in various biological processes such as cell signaling, adhesion, and cell-cell communication and may serve as potential biomarkers when analyzing different diseases. Here, we investigate glycoproteins in narcolepsy type 1 (NT1) disease, a form of narcolepsy characterized by cataplexy-the sudden onset of muscle paralysis that is typically triggered by intense emotions. In this study, 27 human blood serum samples were analyzed, 16 from NT1 patients and 11 from healthy individuals serving as controls. We quantified hydrophilic interaction liquid chromatography (HILIC)-enriched glycopeptides from low-abundance serum samples of controls and NT1 patients via LC-MS/MS. Twenty-eight unique

Indexed as

GlycopeptidesNarcolepsyBiomarkersChromatography, LiquidGlycoproteinsGlycosylationHumansHydrophobic and Hydrophilic InteractionsSerumTandem Mass SpectrometryBiomarkersGlycopeptidesGlycoproteinsbiomarker glycoproteinsHILIC-enriched N-glycopeptidesNT1

Identifiers

PMID38002271
PMCPMC10669497
OpenAlexW4388020607

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.