Evidence map›Paper›PMID 38002235›Full record

ReviewFoods (Basel, Switzerland)2023

The Role of Gluten in Food Products and Dietary Restriction: Exploring the Potential for Restoring Immune Tolerance.

Li Ye, Wenyu Zheng, Xue Li, Wenmin Han, Jialing Shen, Qiuya Lin, Liyan Hou, Lan Liao, Xin'an Zeng

Open access · goldAbstract readReview
In one paragraph

Review in Foods (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. The role of nutrition on thyroid health and disease: myths and facts.Journal of endocrinological investigation · 2026
    Review
  3. Article
  4. Potassium-Rich, Gluten-Free Diets for Patients with Sjögren's Syndrome: A Mini-ReviewEndocrine, metabolic & immune disorders drug targets · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Celiac Disease: Beyond Diet and Food Awareness.Foods (Basel, Switzerland) · 2025
    Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Li YeGuangdong Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China.
Wenyu ZhengGuangdong Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China.
Xue LiGuangdong Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China.
Wenmin HanGuangdong Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China.
Jialing ShenGuangdong Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China.
Qiuya LinGuangdong Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China.
Liyan HouGuangdong Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China.
Lan LiaoGuangdong Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China.ORCID 0000-0002-1004-4344
Xin'an ZengGuangdong Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China.
Foshan University · CN

Funding

National Key Research and Development Program of China 2023YFD2100024Natural Science Foundation of Guangdong Province 2023A1515010904Science and Technology Innovation Special Fund of Guangdong Province 2022B1212010015
6 · The paper itself

Abstract

Wheat is extensively utilized in various processed foods due to unique proteins forming from the gluten network. The gluten network in food undergoes morphological and molecular structural changes during food processing, affecting the final quality and digestibility of the food. The present review introduces the formation of the gluten network and the role of gluten in the key steps of the production of several typical food products such as bread, pasta, and beer. Also, it summarizes the factors that affect the digestibility of gluten, considering that different processing conditions probably affect its structure and properties, contributing to an in-depth understanding of the digestion of gluten by the human body under various circumstances. Nevertheless, consumption of gluten protein may lead to the development of celiac disease (CD). The best way is theoretically proposed to prevent and treat CD by the inducement of oral tolerance, an immune non-response system formed by the interaction of oral food antigens with the intestinal immune system. This review proposes the restoration of oral tolerance in CD patients through adjunctive dietary therapy via gluten-encapsulated/modified dietary polyphenols. It will reduce the dietary restriction of gluten and help patients achieve a comprehensive dietary intake by better understanding the interactions between gluten and food-derived active products like polyphenols.

Indexed as

celiac diseasedietary restrictiondigestibilityfood processinggluteninteractionoral tolerance

Identifiers

PMID38002235
PMCPMC10670377
OpenAlexW4388823719

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.