Evidence map›Paper›PMID 38002044›Full record

ArticleBiomedicines2023

On- vs. Off-Pump CABG in Heart Failure Patients with Reduced Ejection Fraction (HFrEF): A Multicenter Analysis.

Christian Jörg Rustenbach, Stefan Reichert, Medhat Radwan, Isabelle Doll, Migdat Mustafi, Attila Nemeth, Spiros Lukas Marinos, Rafal Berger, Hardy Baumbach, Monika Zdanyte and 15 more

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 4 institutions in 1 country.

Christian Jörg RustenbachDepartment of Thoracic and Cardiovascular Surgery, German Cardiac Competence Center, Eberhard-Karls-University of Tuebingen, 72076 Tübingen, Germany.ORCID 0000-0003-2178-8397
Stefan ReichertDepartment of Thoracic and Cardiovascular Surgery, German Cardiac Competence Center, Eberhard-Karls-University of Tuebingen, 72076 Tübingen, Germany.
Medhat RadwanDepartment of Thoracic and Cardiovascular Surgery, German Cardiac Competence Center, Eberhard-Karls-University of Tuebingen, 72076 Tübingen, Germany.ORCID 0000-0002-0372-3808
Isabelle DollDepartment of Thoracic and Cardiovascular Surgery, German Cardiac Competence Center, Eberhard-Karls-University of Tuebingen, 72076 Tübingen, Germany.
Migdat MustafiDepartment of Thoracic and Cardiovascular Surgery, German Cardiac Competence Center, Eberhard-Karls-University of Tuebingen, 72076 Tübingen, Germany.
Attila NemethDepartment of Thoracic and Cardiovascular Surgery, German Cardiac Competence Center, Eberhard-Karls-University of Tuebingen, 72076 Tübingen, Germany.
Spiros Lukas MarinosDepartment of Thoracic and Cardiovascular Surgery, German Cardiac Competence Center, Eberhard-Karls-University of Tuebingen, 72076 Tübingen, Germany.ORCID 0000-0002-4724-6812
Rafal BergerDepartment of Thoracic and Cardiovascular Surgery, German Cardiac Competence Center, Eberhard-Karls-University of Tuebingen, 72076 Tübingen, Germany.ORCID 0000-0002-8245-4457
Hardy BaumbachIndependent Researcher, Roter-Stich 127, 70376 Stuttgart, Germany.
Monika ZdanyteDepartment of Cardiology, German Cardiac Competence Center, Eberhard-Karls-University of Tuebingen, 72076 Tübingen, Germany.
Helene HaeberleDepartment of Anesthesiology and Intensive Care Medicine, Eberhard-Karls-University of Tuebingen, 72076 Tübingen, Germany.
Tulio CaldonazoDepartment of Cardiothoracic Surgery, Jena University Hospital, 07743 Jena, Germany.
Ibrahim SaqerDepartment of Cardiothoracic Surgery, Jena University Hospital, 07743 Jena, Germany.
Shekhar SahaDepartment of Cardiac Surgery, LMU University Hospital, 80539 Munich, Germany.ORCID 0000-0002-9903-3237
Philipp SchnackenburgDepartment of Cardiac Surgery, LMU University Hospital, 80539 Munich, Germany.
Ilija DjordjevicDepartment of Cardiothoracic Surgery, Heart Center, University of Cologne, 50923 Cologne, Germany.ORCID 0000-0002-5810-8626
Ihor KrasivskyiDepartment of Cardiothoracic Surgery, Heart Center, University of Cologne, 50923 Cologne, Germany.
Stefanie WendtDepartment of Cardiothoracic Surgery, Heart Center, University of Cologne, 50923 Cologne, Germany.ORCID 0000-0001-9956-0953
Elmar KuhnDepartment of Cardiothoracic Surgery, Heart Center, University of Cologne, 50923 Cologne, Germany.
Lina Maria Serna HiguitaInstitute for Clinical Epidemiology and Applied Biostatistics, Eberhard-Karls-University of Tuebingen, 72074 Tübingen, Germany.ORCID 0000-0001-5182-8295
Torsten DoenstDepartment of Cardiothoracic Surgery, Jena University Hospital, 07743 Jena, Germany.
Christian HaglDepartment of Cardiac Surgery, LMU University Hospital, 80539 Munich, Germany.
Thorsten WahlersDepartment of Cardiothoracic Surgery, Heart Center, University of Cologne, 50923 Cologne, Germany.
Rodrigo Sandoval BoburgDepartment of Thoracic and Cardiovascular Surgery, German Cardiac Competence Center, Eberhard-Karls-University of Tuebingen, 72076 Tübingen, Germany.ORCID 0000-0002-4907-7020
Christian SchlensakDepartment of Thoracic and Cardiovascular Surgery, German Cardiac Competence Center, Eberhard-Karls-University of Tuebingen, 72076 Tübingen, Germany.
University of Cologne · DEJena University Hospital · DELMU Klinikum · DEUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to compare postoperative outcomes and 30-day mortality in patients with reduced ejection fraction (<40%) who underwent isolated coronary artery bypass grafting (CABG) with (ONCAB) and without (OPCAB) the use of cardiopulmonary bypass.

methodsdata from four university hospitals in Germany, spanning from January 2017 to December 2021, were retrospectively analyzed. A total of 551 patients were included in the study, and various demographic, intraoperative, and postoperative data were compared.

resultsdemographic parameters did not exhibit any differences. However, the OPCAB group displayed notably higher rates of preoperative renal insufficiency, urgent surgeries, and elevated EuroScore II and STS score. During surgery, the ONCAB group showed a significantly higher rate of complete revascularization, whereas the OPCAB group required fewer intraoperative transfusions. No disparities were observed in 30-day/in-hospital mortality for the entire cohort and the matched population between the two groups. Subsequent to surgery, the OPCAB group demonstrated significantly shorter mechanical ventilation times, reduced stays in the intensive care unit, and lower occurrences of ECLS therapy, acute kidney injury, delirium, and sepsis.

conclusionsthe study's findings indicate that OPCAB surgery presents a safe and viable alternative, yielding improved postoperative outcomes in this specific patient population compared to ONCAB surgery. Despite comparable 30-day/in-hospital mortality rates, OPCAB patients enjoyed advantages such as decreased mechanical ventilation durations, shorter ICU stays, and reduced incidences of ECLS therapy, acute kidney injury, delirium, and sepsis. These results underscore the potential benefits of employing OPCAB as a treatment approach for patients with coronary heart disease and reduced ejection fraction.

Indexed as

coronary artery bypass grafting (CABG)heart failure (HF)heart failure with reduced ejection fraction (HFrEF)off-pump coronary artery bypass grafting (OPCAB)total-arterial revascularization (TAR)

Identifiers

PMID38002044
PMCPMC10669606
OpenAlexW4388659787

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.