Evidence map›Paper›PMID 38001943›Full record

ArticleBiomedicines2023

Characterization of a Human Neuronal Culture System for the Study of Cofilin-Actin Rod Pathology.

Lubna H Tahtamouni, Sydney A Alderfer, Thomas B Kuhn, Laurie S Minamide, Soham Chanda, Michael R Ruff, James R Bamburg

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Amyloid Beta Oligomers as Early Triggers of Neuronal Cytoskeleton Dysfunction in Alzheimer's Disease.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Lubna H TahtamouniDepartment of Biology and Biotechnology, Faculty of Science, The Hashemite University, Zarqa 13133, Jordan.
Sydney A AlderferDepartment of Chemical and Biological Engineering and School of Biomedical Engineering, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0009-0005-4997-6164
Thomas B KuhnDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA.
Laurie S MinamideDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA.
Soham ChandaDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA.
Michael R RuffCreative Bio-Peptides, Inc., 10319 Glen Road, Suite 100, Potomac, MD 20854, USA.
James R BamburgDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0003-3767-3586
Colorado State University · USHashemite University · JO

Funding

Cellular Mechanisms of Neuroligin-4 Gene in Human NeuronsR01MH126017 · NIMH · COLORADO STATE UNIVERSITY · PI Soham Chanda · 2022 to 2026
$1.8M
Optimization of a Chemokine Receptor Antagonist Peptide as a Synapse Protecting Treatment for Neurodegeneration in Alzheimer's DiseaseR43AG074715 · NIA · CREATIVE BIO-PEPTIDES, INC. · PI RUFF, MICHAEL R · 2021 to 2021
$500k
Development of a Novel Chemokine Receptor Antagonist Peptide as a Synapse Protecting Treatment for Neurodegeneration in Alzheimer's DiseaseR43AG071064 · NIA · CREATIVE BIO-PEPTIDES, INC. · PI RUFF, MICHAEL R · 2020 to 2020
$449k
Fluorescence Microscope for Automated Large Array Scanning and 3D imagingS10OD025127 · OD · COLORADO STATE UNIVERSITY · PI BAMBURG, JAMES R · 2018 to 2018
$188k
NIA NIH HHS R43 AG071064NIA NIH HHS R43 AG074715NIH HHS 1R43 AG071064, 1R43 AG074715, 1S10 0D025127NIH HHS S10 OD025127NIMH NIH HHS R01 MH126017
6 · The paper itself

Abstract

Cofilactin rod pathology, which can initiate synapse loss, has been extensively studied in rodent neurons, hippocampal slices, and in vivo mouse models of human neurodegenerative diseases such as Alzheimer's disease (AD). In these systems, rod formation induced by disease-associated factors, such as soluble oligomers of Amyloid-β (Aβ) in AD, utilizes a pathway requiring cellular prion protein (PrP

Indexed as

amyloid-βcellular prion proteincofilactin rodscofilincytokine/chemokine receptorshuman iPSCsNADPH oxidasesynapse developmentWTC-11 cells

Identifiers

PMID38001943
PMCPMC10669520
OpenAlexW4388079926

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.