Evidence map›Paper›PMID 38001716›Full record

ArticleCancers2023

A Retrospective Multicenter Italian Analysis of Epidemiological, Clinical and Histopathological Features in a Sample of Patients with Acinic Cell Carcinoma of the Parotid Gland.

Pietro De Luca, Arianna Di Stadio, Luca de Campora, Egidio De Bonis, Matteo Fermi, Gerardo Petruzzi, Francesca Atturo, Roberta Colangeli, Alfonso Scarpa, Alfredo Lo Manto and 35 more

Open access · goldAbstract read
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In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. 3D exoscopic assisted parotidectomy: practical considerations from a preliminary case series.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. In Reference to "Surgical Outcomes of U-Shaped Incisions Versus Conventional Incisions in Parotidectomy".Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors at 18 institutions in 1 country.

Pietro De LucaOtolaryngology Department, Fatebenefratelli Isola Tiberina-Gemelli Isola, 00186 Rome, Italy.ORCID 0000-0002-6505-1680
Arianna Di StadioOtolaryngology Unit, University of Catania, 95131 Catania, Italy.ORCID 0000-0001-5510-3814
Luca de CamporaOtolaryngology Department, San Giovanni-Addolorata Hospital, 00100 Rome, Italy.
Egidio De BonisOtolaryngology Unit, San Giovanni di Dio e Ruggi D'Aragona Hospital, 84131 Salerno, Italy.
Matteo FermiDepartment of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0000-0002-2727-0321
Gerardo PetruzziDepartment Otolaryngology Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, Istituti Fisioterapici Ospitalieri (IFO), 00144 Rome, Italy.ORCID 0000-0003-0371-7667
Francesca AtturoOtolaryngology Department, San Giovanni-Addolorata Hospital, 00100 Rome, Italy.
Roberta ColangeliOtolaryngology Department, Sant'Eugenio Hospital, 00144 Rome, Italy.
Alfonso ScarpaDepartment of Medicine, Surgery and Dentistry, University of Salerno, 84081 Salerno, Italy.
Alfredo Lo MantoOtolaryngology Department, University of Modena and Reggio Emilia, 41121 Modena, Italy.
Andrea ColizzaDepartment of Sense Organs, University Sapienza, 00161 Rome, Italy.ORCID 0000-0002-0639-806X
Giulia CintoliOtolaryngology Unit, University of Foggia, 71122 Foggia, Italy.
Giulia TogoMaxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", 80100 Naples, Italy.
Giovanni SalzanoMaxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", 80100 Naples, Italy.
Domenico CrescenziOtolaryngology Department, Fatebenefratelli Isola Tiberina-Gemelli Isola, 00186 Rome, Italy.
Massimo RalliDepartment of Sense Organs, University Sapienza, 00161 Rome, Italy.ORCID 0000-0001-8776-0421
Vincenzo AbbateMaxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", 80100 Naples, Italy.ORCID 0000-0002-7905-0531
Filippo RicciardielloOtolaryngology Unit, AORN Cardarelli, 80131 Naples, Italy.
Luciano MagaldiOtolaryngology Unit, University of Foggia, 71122 Foggia, Italy.
Aurelio D'EcclesiaMaxillofacial and Otolaryngology Unit, IRCCS "Casa Sollievo della Sofferenza" San Giovanni Rotondo, 71013 Foggia, Italy.
Gianluca di MassaDepartment of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, 41124 Modena, Italy.
Leopoldo CostarelliDepartment of Pathology, San Giovanni Addolorata-Hospital, 00184 Rome, Italy.ORCID 0000-0002-9545-8123
Elisabetta MerendaDepartment of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-7231-2295
Alessandro CorsiDepartment of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-6896-4509
Renato CovelloDepartment of Pathology, IRCCS-Regina Elena National Cancer Institute, 00144 Rome, Italy.
Rosa Maria Di CrescenzoInstitute of Experimental Endocrinology and Oncology (IEOS), National Research Council, 80131 Naples, Italy.
Loren DudaPathology Unit, Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy.
Lucia Maria DimitriDepartment of Pathology, IRCCS "Casa Sollievo della Sofferenza" San Giovanni Rotondo, 71013 Foggia, Italy.
Alessandro CaputoPathology Unit, San Giovanni di Dio e Ruggi D'Aragona University Hospital, 84131 Salerno, Italy.
Gerardo FerraraDepartment of Pathology, INT-IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.
Teresina LucanteDepartment of Pathology, Fatebenefratelli Isola Tiberina-Gemelli Isola, 00186 Rome, Italy.
Francesco LongoMaxillofacial and Otolaryngology Unit, IRCCS "Casa Sollievo della Sofferenza" San Giovanni Rotondo, 71013 Foggia, Italy.ORCID 0000-0002-7605-2953
Domenico TassoneOtolaryngology Department, San Giovanni-Addolorata Hospital, 00100 Rome, Italy.
Maurizio IemmaOtolaryngology Unit, San Giovanni di Dio e Ruggi D'Aragona Hospital, 84131 Salerno, Italy.
Michele CassanoOtolaryngology Unit, University of Foggia, 71122 Foggia, Italy.
Francesco Antonio SalzanoDepartment of Medicine, Surgery and Dentistry, University of Salerno, 84081 Salerno, Italy.
Luigi CalifanoMaxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", 80100 Naples, Italy.
Daniele MarchioniOtolaryngology Department, University of Modena and Reggio Emilia, 41121 Modena, Italy.
Raul PelliniDepartment Otolaryngology Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, Istituti Fisioterapici Ospitalieri (IFO), 00144 Rome, Italy.ORCID 0000-0001-6051-3041
Marco de VincentiisDepartment of Sense Organs, University Sapienza, 00161 Rome, Italy.
Livio PresuttiDepartment of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Franco IonnaMaxillofacial Unit, INT-IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.
Enrico de CamporaAssociazione Ospedaliera Italia Centro-Meridionale Otorinolaringoiatrica (AOICO), 00100 Rome, Italy.
Marco RadiciOtolaryngology Department, Fatebenefratelli Isola Tiberina-Gemelli Isola, 00186 Rome, Italy.
Angelo CamaioniOtolaryngology Department, San Giovanni-Addolorata Hospital, 00100 Rome, Italy.
Azienda Ospedaliera San Giovanni Addolorata · ITSapienza University of Rome · ITFatebenefratelli Hospital · ITUniversity of Foggia · ITUniversity of Naples Federico II · ITCasa Sollievo della Sofferenza · ITOspedali Riuniti San Giovanni di Dio e Ruggi d'Aragona · ITUniversity of Modena and Reggio Emilia · ITAzienda USL di Bologna · ITIstituti Fisioterapici Ospitalieri · ITIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITUniversity of Salerno · ITAzienda Ospedaliero Universitaria Ospedali Riuniti · ITInstitute for Experimental Endocrinology and Oncology · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITOspedale Antonio Cardarelli · ITSt. Eugenio Hospital · ITUniversity of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe acinic cell carcinoma (AciCC) of the parotid gland is a rare tumor with an indolent behavior; however, a subgroup of this tumor presents an aggressive behavior with a tendency to recur. The aim of this multicenter study was to identify and stratify those patients with AciCC at high risk of tumor recurrence.

methodsA retrospective study was carried out involving 77 patients treated with surgery between January 2000 and September 2022, in different Italian referral centers. Data about tumor characteristics and its recurrence were collected. The histological specimens and slides were independently reviewed by a senior pathologist coordinator (L.C.) and the institution's local head and neck pathologist.

resultsThe patients' age average was 53.6 years, with a female prevalence in the group. The mean follow-up was 67.4 months (1-258, SD 59.39). The five-year overall survival (OS) was 83.2%. The 5-year disease-free survival (DFS) was 60% (95% CI 58.2-61.7). A high incidence of necrosis, extraglandular spread, lymphovascular invasion (LVI), atypical mitosis, and cellular pleomorphism was observed in the high-risk tumors compared to the low-risk ones.

conclusionAciCC generally had an indolent behavior, optimal OS, DFS with few cervical node metastases, and rare distant relapses. This multicenter retrospective case series provides evidence of the need for clinical-epidemiological-histological stratification for patients at risk of poor outcomes. Our results suggest that the correct definition of high-risk AciCC should include tumor size, the presence of necrosis, extraglandular spread, LVI, atypical mitosis, and cellular pleomorphism.

Indexed as

acinic cell carcinomaneck dissectionparotidparotidectomysalivary gland

Identifiers

PMID38001716
PMCPMC10669973
OpenAlexW4388761986

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.