Evidence map›Paper›PMID 38001699›Full record

ArticleCancers2023

Ring Chromosomes in Hematological Malignancies Are Associated with

Rachel J Boyd, Jaclyn B Murry, Laura A Morsberger, Melanie Klausner, Suping Chen, Christopher D Gocke, Andrew S McCallion, Ying S Zou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Genes · 2025
    Article
  2. Article
  3. Article
  4. CanPharmaceuticals (Basel, Switzerland) · 2024
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Rachel J BoydMcKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Jaclyn B MurryJohns Hopkins Genomics, Baltimore, MD 21205, USA.
Laura A MorsbergerJohns Hopkins Genomics, Baltimore, MD 21205, USA.
Melanie KlausnerJohns Hopkins Genomics, Baltimore, MD 21205, USA.
Suping ChenJohns Hopkins Genomics, Baltimore, MD 21205, USA.
Christopher D GockeJohns Hopkins Genomics, Baltimore, MD 21205, USA.ORCID 0000-0002-9541-2192
Andrew S McCallionMcKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Ying S ZouJohns Hopkins Genomics, Baltimore, MD 21205, USA.ORCID 0000-0003-2787-1917
Johns Hopkins University · US

Funding

Robust Methods for Polygenic Analysis to Inform Disease Etiology and Enhance Risk PredictionR01HG010480 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI CHATTERJEE, NILANJAN · 2019 to 2023
$2.8M
Predoctoral Training Program in Human GeneticsT32GM148383 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Kimberly F Doheny, ANDREW S MCCALLION · 2023 to 2026
$2.4M
Determination of the clinical relevance of Parkinson disease-associated intronic enhancer of the alpha-synuclein gene, in a novel mouse deletion modelR21NS128604 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KO, HANSEOK, MCCALLION, ANDREW S · 2023 to 2024
$450k
CIHR DFD-181599NHGRI NIH HHS R01 HG010480NIGMS NIH HHS T32 GM148383NIH HHS R01HG010480, R21NS128604NINDS NIH HHS R21 NS128604
6 · The paper itself

Abstract

Ring chromosomes (RC) are present in <10% of patients with hematological malignancies and are associated with poor prognosis. Until now, only small cohorts of patients with hematological neoplasms and concomitant RCs have been cytogenetically characterized. Here, we performed a conventional chromosome analysis on metaphase spreads from >13,000 patients diagnosed with hematological malignancies at the Johns Hopkins University Hospital and identified 98 patients with RCs-90 with myeloid malignancies and 8 with lymphoid malignancies. We also performed a targeted Next-Generation Sequencing (NGS) assay, using a panel of 642 cancer genes, to identify whether these patients harbor relevant pathogenic variants. Cytogenetic analyses revealed that RCs and marker chromosomes of unknown origin are concurrently present in most patients by karyotyping, and 93% of patients with NGS data have complex karyotypes. A total of 72% of these individuals have pathogenic mutations in

Indexed as

complex karyotypecopy number variantsgene mutationmyeloid malignanciesring chromosomes

Identifiers

PMID38001699
PMCPMC10670249
OpenAlexW4388734777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.