Evidence map›Paper›PMID 38001697›Full record

ReviewCancers2023

Optical Imaging in Human Lymph Node Specimens for Detecting Breast Cancer Metastases: A Review.

Maria Papadoliopoulou, Maria Matiatou, Spyridon Koutsoumpos, Francesk Mulita, Panagiotis Giannios, Ioannis Margaris, Konstantinos Moutzouris, Nikolaos Arkadopoulos, Nikolaos V Michalopoulos

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Maria Papadoliopoulou4th Department of Surgery, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 1 Rimini Street, 12462 Athens, Greece.
Maria MatiatouLaboratory of Electronic Devices and Materials, Department of Electrical & Electronic Engineering, University of West Attica, 12244 Egaleo, Greece.
Spyridon KoutsoumposLaboratory of Electronic Devices and Materials, Department of Electrical & Electronic Engineering, University of West Attica, 12244 Egaleo, Greece.ORCID 0000-0002-6079-2199
Francesk MulitaDepartment of Surgery, General University Hospital of Patras, 26504 Rio, Greece.ORCID 0000-0001-7198-2628
Panagiotis GianniosBarcelona Institute of Science and Technology, Institute for Research in Biomedicine, IRB Barcelona, 08028 Barcelona, Spain.ORCID 0000-0002-7881-1431
Ioannis Margaris4th Department of Surgery, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 1 Rimini Street, 12462 Athens, Greece.
Konstantinos MoutzourisLaboratory of Electronic Devices and Materials, Department of Electrical & Electronic Engineering, University of West Attica, 12244 Egaleo, Greece.ORCID 0000-0003-3486-5865
Nikolaos Arkadopoulos4th Department of Surgery, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 1 Rimini Street, 12462 Athens, Greece.
Nikolaos V Michalopoulos4th Department of Surgery, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 1 Rimini Street, 12462 Athens, Greece.
National and Kapodistrian University of Athens · GRUniversity of West Attica · GRGeneral University Hospital of Patras · GRInstitute for Research in Biomedicine · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Assessment of regional lymph node status in breast cancer is of important staging and prognostic value. Even though formal histological examination is the currently accepted standard of care, optical imaging techniques have shown promising results in disease diagnosis. In the present article, we review six spectroscopic techniques and focus on their use as alternative tools for breast cancer lymph node assessment. Elastic scattering spectroscopy (ESS) seems to offer a simple, cost-effective, and reproducible method for intraoperative diagnosis of breast cancer lymph node metastasis. Optical coherence tomography (OCT) provides high-resolution tissue scanning, along with a short data acquisition time. However, it is relatively costly and experimentally complex. Raman spectroscopy proves to be a highly accurate method for the identification of malignant axillary lymph nodes, and it has been further validated in the setting of head and neck cancers. Still, it remains time-consuming. Near-infrared fluorescence imaging (NIRF) and diffuse reflectance spectroscopy (DFS) are related to significant advantages, such as deep tissue penetration and efficiency. Fourier-transform infrared spectroscopy (FTIR) is a promising method but has significant drawbacks. Nonetheless, only anecdotal reports exist on their clinical use for cancerous lymph node detection. Our results indicate that optical imaging methods can create informative and rapid tools to effectively guide surgical decision-making.

Indexed as

diffuse reflectance spectroscopyelastic scattering spectroscopyFourier-transform infrared spectroscopylymph node assessmentnear-infrared fluorescence imagingoptical coherence tomographyRaman spectroscopyspectroscopic techniques

Identifiers

PMID38001697
PMCPMC10670418
OpenAlexW4388731933

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.