Evidence map›Paper›PMID 38001638›Full record

ArticleCancers2023

ARID1A Deficiency Regulates Anti-Tumor Immune Response in Esophageal Adenocarcinoma.

Le Zhang, Yueyuan Zheng, Wenwen Chien, Benjamin Ziman, Sandrine Billet, H Phillip Koeffler, De-Chen Lin, Neil A Bhowmick

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Le ZhangDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.ORCID 0000-0002-1899-4598
Yueyuan ZhengDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Wenwen ChienDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Benjamin ZimanDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.ORCID 0000-0003-0951-3534
Sandrine BilletDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
H Phillip KoefflerDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
De-Chen LinDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Neil A BhowmickDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.ORCID 0000-0001-8747-5989
Cedars-Sinai Medical Center · USUniversity of Southern California · US

Funding

The paradoxical roles of beta hydroxy butyrate in the liver pro-metastatic nicheP01CA233452 · NCI · CEDARS-SINAI MEDICAL CENTER · PI LU, SHELLY CHI-LOO · 2020 to 2024
$9.5M
Master regulator transcription factors promote esophageal neoplastic evolutionR37CA237022 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LIN, DE-CHEN · 2020 to 2025
$2.7M
NCI NIH HHS CA233452NCI NIH HHS P01 CA233452NCI NIH HHS R37 CA237022
6 · The paper itself

Abstract

ARID1A, a member of the chromatin remodeling SWI/SNF complex, is frequently lost in many cancer types, including esophageal adenocarcinoma (EAC). Here, we study the impact of ARID1A deficiency on the anti-tumor immune response in EAC. We find that EAC tumors with ARID1A mutations are associated with enhanced tumor-infiltrating CD8

Indexed as

ARID1ACD8+ T cellsesophageal adenocarcinomaIFN responselipid metabolismtumor immunity

Identifiers

PMID38001638
PMCPMC10670331
OpenAlexW4388637731

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.