SynthesisBMC cancer2023
Oxidative balance score and risk of cancer: a systematic review and meta-analysis of observational studies.
Synthesis in BMC cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Oxidative balance score, genetic susceptibility, and the risk of pancreatic cancer: a population-based cohort study.Nutrition journal · 2026Article
- Association between the oxidative balance score and all-cause mortality in patients with cardiovascular disease-cancer comorbidity.Journal of health, population, and nutrition · 2026Article
- Negative association between oxidative balance score and stroke prevalence in US adults with metabolic syndrome: mediating roles of HDL-C and NHHR.European journal of medical research · 2025Article
- Oxidative balance score and all-cause mortality among hypertensive individuals.Journal of global health · 2025Article
- Observational
- Lifestyle Medicine as a Pathway to Longevity: The Impact of the Healthy Lifestyle Community Program (Cohort 2, HLCP-2) on Oxidative Stress Biomarkers in the Adult Rural German Population.American journal of lifestyle medicine · 2025Article
- Assessment of oxidative balance score with hypertension and arterial stiffness in children and adolescents: NHANES 2001-2018.European journal of nutrition · 2025Article
- Association of oxidative balance scores with the prevalence of prediabetes, impaired fasting glucose, and impaired glucose tolerance in the general US adult population: Evidence from NHANES 1999-2018.The Journal of international medical research · 2025Article
- The impact of oxidative balance on all-cause and cause-specific mortality in US adults and cancer survivors: evidence from NHANES 2001-2018.BMC cancer · 2025Article
- Association between oxidative balance score and osteosarcopenia in US adults: insights from a population-based study.Frontiers in nutrition · 2025Article
- Association between oxidative balance score with cardiovascular - kidney - metabolic syndrome and all-cause mortality among US population.Frontiers in nutrition · 2025Article
- The association between oxidative balance scores and all-cause mortality and cancer-specific mortality in cancer survivors: a retrospective cohort study.Frontiers in nutrition · 2025Article
- Age-dependent association between lifestyle oxidative balance score and bone mineral density in children and adolescents: evidence from the NHANES 2015-2018.Frontiers in physiology · 2025Article
- Association Between Oxidative Balance Score and Gynecological Cancer Using NHANES 2011-2018 Data.International journal of women's health · 2025Article
- Cellular and molecular roles of reactive oxygen species in wound healing.Communications biology · 2024Review
- Association between oxidative balance score and abdominal aortic calcification among middle-aged and elderly population.BMC cardiovascular disorders · 2024Article
- Adherence to an antioxidant diet and lifestyle is associated with reduced risk of cardiovascular disease and mortality among adults with nonalcoholic fatty liver disease: evidence from NHANES 1999-2018.Frontiers in nutrition · 2024Article
- Oxidative balance score: a potential tool for reducing the risk of colorectal cancer and its subsites incidences.Frontiers in endocrinology · 2024Article
- Association between oxidative balance score and metabolic syndrome and its components in US adults: a cross-sectional study from NHANES 2011-2018.Frontiers in nutrition · 2024Article
- Association Between the Oxidative Balance Score and Endometriosis: A Population-Based Study.International journal of women's health · 2024Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe oxidative balance score (OBS) has been utilized to assess the overall pro- and antioxidant exposure status in various chronic diseases. The current meta-analysis was carried out to pool the association between OBS and the risk of cancer.
methodsWe systematically searched the Web of Science, PubMed, Scopus, Embase, and Google Scholar up to August 2023. All observational studies which evaluated the association of OBS with the risk of cancers were included. There was no time of publication or language restrictions. Heterogeneity between studies was assessed using the Chi-square-based Q-test and the I
resultsTotally, 15 studies (9 case-control and 6 cohorts) were eligible for meta-analysis. Random effect model meta-analysis of case-control studies showed that higher OBS significantly decreases the odds of cancers (pooled OR: 0.64, 95% CI: 0.54, 0.74). In the cohort studies, the association of OBS with the risk of cancers was not significant (pooled HR: 0.97, 95% CI: 0.80,1.18). The subgroup analysis showed that cancer type and gender were the potential sources of heterogeneity.
conclusionOur results show an inverse and significant association between higher OBS and odds of colorectal cancers in case-control and cohort studies. In the case of prostate cancer in cohort studies, our results did not align with the hypothesis. Considering the importance of diet and antioxidant balance in the conditions of malignancy, it is suggested to conduct more comprehensive studies with standard measurement methods to obtain conclusive results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.