Evidence map›Paper›PMID 38001284›Full record

ArticleThe Journal of antibiotics2024

Evaluation of A-ring hydroxymethylene-amino- triterpenoids as inhibitors of SARS-CoV-2 spike pseudovirus and influenza H1N1.

Oxana Kazakova, Xinyuan Ma, Elena Tretyakova, Irina Smirnova, Alexander Slita, Ekaterina Sinegubova, Vladimir Zarubaev, Hongwei Jin, Demin Zhou, Sulong Xiao

Abstract read
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In one paragraph

Article in The Journal of antibiotics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Oxana KazakovaUfa Institute of Chemistry UFRC RAS, pr. Oktyabrya 71, 450054, Ufa, Russia. obf@anrb.ru.
Xinyuan MaState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Elena TretyakovaUfa Institute of Chemistry UFRC RAS, pr. Oktyabrya 71, 450054, Ufa, Russia.
Irina SmirnovaUfa Institute of Chemistry UFRC RAS, pr. Oktyabrya 71, 450054, Ufa, Russia.ORCID 0000-0001-7176-505X
Alexander SlitaDepartment of Virology, St. Petersburg Pasteur Institute of Epidemiology and Microbiology, Experimental Virology Laboratory, 14 Mira St., St. Petersburg, 197001, Russia.
Ekaterina SinegubovaDepartment of Virology, St. Petersburg Pasteur Institute of Epidemiology and Microbiology, Experimental Virology Laboratory, 14 Mira St., St. Petersburg, 197001, Russia.
Vladimir ZarubaevDepartment of Virology, St. Petersburg Pasteur Institute of Epidemiology and Microbiology, Experimental Virology Laboratory, 14 Mira St., St. Petersburg, 197001, Russia.
Hongwei JinState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Demin ZhouState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Sulong XiaoState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China. slxiao@bjmu.edu.cn.ORCID 0000-0002-6852-9504

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82161148006Russian Foundation for Basic Research (RFBR) 20-53-55001
6 · The paper itself

Abstract

A set of triterpene A-ring hydroxymethylene-amino-derivatives was synthesized and their antiviral activity was studied. The synthesized compounds were tested for their potential inhibition of SARS-CoV-2 pseudovirus in BHK-21-hACE2 cells and influenza A/PuertoRico/8/34 (H1N1) virus in MDCK cell culture. Compounds 6, 8 and 19 showed significant anti-SARS-CoV-2 pseudovirus activity with EC

Indexed as

COVID-19Influenza A Virus, H1N1 SubtypeInfluenza, HumanTriterpenesAntiviral AgentsHumansMolecular Docking SimulationProtein BindingSARS-CoV-2Antiviral AgentsTriterpenes

Identifiers

PMID38001284

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.