Evidence map›Paper›PMID 38001113›Full record

ArticleNature communications2023

ACS-20/FATP4 mediates the anti-ageing effect of dietary restriction in C. elegans.

Zi Wang, Lina Zou, Yiyan Zhang, Mengnan Zhu, Shuxian Zhang, Di Wu, Jianfeng Lan, Xiao Zang, Qi Wang, Hanxin Zhang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Zi WangModel Animal Research Center of Medical School, MOE Key Laboratory of Model Animals for Disease Study, Nanjing University, Nanjing, Jiangsu, 210061, China.
Lina ZouModel Animal Research Center of Medical School, MOE Key Laboratory of Model Animals for Disease Study, Nanjing University, Nanjing, Jiangsu, 210061, China.
Yiyan ZhangModel Animal Research Center of Medical School, MOE Key Laboratory of Model Animals for Disease Study, Nanjing University, Nanjing, Jiangsu, 210061, China.ORCID 0000-0001-8442-2152
Mengnan ZhuSchool of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Shuxian ZhangSchool of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Di WuInstitute of Drug Discovery and Development, Center for Drug Safety Evaluation and Research, Zhengzhou University, Zhengzhou, Henan, 450001, China.
Jianfeng LanAffiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541001, China.
Xiao ZangModel Animal Research Center of Medical School, MOE Key Laboratory of Model Animals for Disease Study, Nanjing University, Nanjing, Jiangsu, 210061, China.
Qi WangModel Animal Research Center of Medical School, MOE Key Laboratory of Model Animals for Disease Study, Nanjing University, Nanjing, Jiangsu, 210061, China.
Hanxin ZhangModel Animal Research Center of Medical School, MOE Key Laboratory of Model Animals for Disease Study, Nanjing University, Nanjing, Jiangsu, 210061, China.
Zixing WuModel Animal Research Center of Medical School, MOE Key Laboratory of Model Animals for Disease Study, Nanjing University, Nanjing, Jiangsu, 210061, China.
Huanhu ZhuSchool of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.ORCID 0000-0002-5070-9531
Di ChenModel Animal Research Center of Medical School, MOE Key Laboratory of Model Animals for Disease Study, Nanjing University, Nanjing, Jiangsu, 210061, China. dic@intl.zju.edu.cn.ORCID 0000-0002-0514-7947
Model Animal Research Center · CNShanghaiTech University · CNGuilin Medical University · CNZhengzhou University · CN

Funding

National Natural Science Foundation of China (National Science Foundation of China) 31671527National Natural Science Foundation of China (National Science Foundation of China) 31971092National Natural Science Foundation of China (National Science Foundation of China) 32171156
6 · The paper itself

Abstract

Dietary restriction is an effective anti-ageing intervention across species. However, the molecular mechanisms from the metabolic aspects of view are still underexplored. Here we show ACS-20 as a key mediator of dietary restriction on healthy ageing from a genetic screen of the C. elegans acyl-CoA synthetase family. ACS-20 functions in the epidermis during development to regulate dietary restriction-induced longevity. Functional transcriptomics studies reveal that elevated expression of PTR-8/Patched is responsible for the proteostasis and lifespan defects of acs-20. Furthermore, the conserved NHR-23 nuclear receptor serves as a transcriptional repressor of ptr-8 and a key regulator of dietary restriction-induced longevity. Mechanistically, a specific region in the ptr-8 promoter plays a key role in mediating the transcription regulation and lifespan extension under dietary restriction. Altogether, these findings identify a highly conserved lipid metabolism enzyme as a key mediator of dietary restriction-induced lifespan and healthspan extension and reveal the downstream transcriptional regulation mechanisms.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsAgingAnimalsCaloric RestrictionCarrier ProteinsLongevityTranscription FactorsCaenorhabditis elegans ProteinsCarrier ProteinsTranscription Factors

Identifiers

PMID38001113
PMCPMC10673863
OpenAlexW4388993461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.